The Search for Biomarkers of Long-Term Outcome after Preterm Birth.
The Search for Biomarkers of Long-Term Outcome after Preterm Birth.
复制标题
寻找早产后长期结果的生物标志物。
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
N. Modi
中科院分区：
文献类型：
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作者：
J. Parkinson;M. Hyde;N. Modi
全球早产率和存活率正在上升，因此，保障终身健康的必要性越来越大。来自世界各地的流行病学和其他研究表明，早产后成人健康不良后果的风险更高。这些报告涵盖了多个领域的疾病、生殖健康较差和寿命缩短。遗传、宫内暴露和产后护理措施对这种改变的成人表型的作用尚不清楚。早期发现对于实施预防措施和测试保护性产前和新生儿干预措施以减少异常健康轨迹至关重要。一个令人满意的预后生物标记物必须预测以后的功能健康，理想的情况是在从婴儿期到儿童期和成年期保持稳定。到目前为止，血压是最符合这些标准的指标。高通量的“组学”技术可能识别未来结果和健康风险的生物标记物。然而，它们的潜力只能通过对大型纵向队列研究的初始投资才能实现，这些研究将连续代谢组谱与整个生命过程中的功能健康评估结合在一起。
Preterm birth and survival rates are rising globally, and consequently there is a growing necessity to safeguard life-long health. Epidemiological and other studies from around the world point to a higher risk of adverse adult health outcomes following preterm birth. These reports encompass morbidities in multiple domains, poorer reproductive health, and reduced longevity. The contributions of genetic inheritance, intrauterine exposures, and postnatal care practices to this altered adult phenotype are not known. Early detection is essential to implement preventive measures and to test protective antenatal and neonatal interventions to attenuate aberrant health trajectories. A satisfactory biomarker of outcome must be predictive of later functional health and ideally remain stable over the period from infancy to childhood and adult life. To date, blood pressure is the index that best fulfils these criteria. High throughput 'omic' technologies may identify biomarkers of later outcome and health risk. However, their potential can only be realized with initial investment in large, longitudinal cohort studies, which couple serial metabolomic profiling with functional health assessments across the life course.
影响因子：
15.9
作者：
Wang, Thomas J.;Ngo, Debby;Gerszten, Robert E.
通讯作者：
Gerszten, Robert E.
影响因子：
8
作者：
Freedman, DS;Khan, LK;Berenson, GS
通讯作者：
Berenson, GS
影响因子：
120.7
作者：
Crump, Casey;Sundquist, Kristina;Winkleby, Marilyn A.
通讯作者：
Winkleby, Marilyn A.