High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome
High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome
复制标题
多系统萎缩和皮质基底节综合征患者血清抗 α-烯醇化酶抗体 NH2 末端的高患病率
DOI：
10.1007/s00415-021-10553-2
复制
发表时间：
2021
期刊：
影响因子：
6
通讯作者：
Aoki M
中科院分区：
文献类型：
--
作者：
Kikuchi A;Yoneda M;Hasegawa T;Matsunaga A;Ikawa M;Nakamura T;Ezura M;Baba T;Sugeno N;Ishiyama S;Nakamoto Y;Takeda A;Aoki M
背景：血清抗α-烯醇化酶氨基末端（NAE）抗体阳性的桥本脑病，临床上偶尔表现为小脑性共济失调和帕金森综合征。方法检测47例多系统萎缩（MSA）、29例帕金森病（PD）、8例皮质基底动脉综合征（CBS）、10例帕金森病（PD）患者血清中NAE抗体的阳性率。结果抗NAE抗体阳性率为31.9%，MSA、PD、CBS和PSP患者分别报告了10.3%、50.0%和11.1%。血清阳性MSA患者从发病到轮椅束缚状态的持续时间往往短于血清阴性MSA patients.ConclusionsAnti-NAE抗体检测在一些临床诊断为MSA和CBS的患者。虽然其病理生理意义仍然不确定，血清抗NAE抗体可能代表MSA的临床过程中的预后标志物。
BackgroundHashimoto’s encephalopathy with serum anti-NH2-terminal of α-enolase (NAE) antibodies occasionally displays clinical symptoms such as cerebellar ataxia and parkinsonism. We studied the frequency of anti-NAE antibodies in patients with Parkinson-plus syndrome.MethodsWe examined the positive rates of anti-NAE antibodies in 47 patients with multiple system atrophy (MSA), 29 patients with Parkinson’s disease (PD), eight patients with corticobasal syndrome (CBS), and 18 patients with progressive supranuclear palsy (PSP) using conventional immunoblot analysis.ResultsPositive anti-NAE antibody rates of 31.9%, 10.3%, 50.0%, and 11.1% were reported in the MSA, PD, CBS, and PSP patients, respectively. The duration from onset to a wheelchair-bound state in seropositive MSA patients tended to be shorter than that in seronegative MSA patients.ConclusionsAnti-NAE antibodies are detected in some patients clinically diagnosed with MSA and CBS. Although its pathophysiological significance remains uncertain, serum anti-NAE antibodies might represent a prognostic marker in the clinical course of MSA.
登录
查看更多内容
影响因子：
3.3
作者：
Fujii, A;Yoneda, M;Kuriyama, M
通讯作者：
Kuriyama, M
影响因子：
11
作者：
Mathew, Robert;Bak, Thomas H.;Hodges, John R.
通讯作者：
Hodges, John R.
影响因子：
2.6
作者：
Novak P;Williams A;Ravin P;Zurkiya O;Abduljalil A;Novak V
通讯作者：
Novak V
DOI：
--
发表时间：
2020
期刊：
--
影响因子：
--
作者：
M. Yoneda;A. Matsunaga;M. Ikawa
通讯作者：
M. Ikawa
影响因子：
2.4
作者：
Matsunaga, Akiko;Ikawa, Masamichi;Yoneda, Makoto
通讯作者：
Yoneda, Makoto