Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis.
Regulatory T Cell-Enhancing Therapies to Treat Atherosclerosis.
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调节性T细胞增强疗法治疗动脉粥样硬化。
DOI：
10.3390/cells10040723
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发表时间：
2021-03-24
期刊：
影响因子：
6
通讯作者：
Tedgui A
中科院分区：
文献类型：
--
作者：
Ait-Oufella H;Lavillegrand JR;Tedgui A
实验研究已经提供了强有力的证据表明，由动脉中富含胆固醇的脂蛋白的内皮下积聚触发的慢性炎症在动脉粥样硬化的起始和进展中是必不可少的。最近的临床试验强调了抗炎疗法在冠状动脉患者中的功效，已经证实这在人类中也是真实的。单核细胞/巨噬细胞是动脉粥样硬化过程中的中心细胞，但是通过B和T淋巴细胞以及树突细胞的适应性免疫也调节疾病的进展。对不同T细胞亚群在动脉粥样硬化小鼠模型中的作用进行分析，发现效应性Th 1细胞具有致动脉粥样硬化作用，而调节性T细胞（TCFs）已被证明具有抗动脉粥样硬化作用。由于这些原因，更好地了解Treg如何影响动脉粥样硬化过程被认为提供了新的Treg靶向治疗来对抗动脉粥样硬化。这篇综述文章总结了目前的知识Tcl 4在动脉粥样硬化中的作用，并讨论了如何提高其功能作为新的免疫调节治疗方法对心血管疾病。
Experimental studies have provided strong evidence that chronic inflammation triggered by the sub-endothelial accumulation of cholesterol-rich lipoproteins in arteries is essential in the initiation and progression of atherosclerosis. Recent clinical trials highlighting the efficacy of anti-inflammatory therapies in coronary patients have confirmed that this is also true in humans Monocytes/macrophages are central cells in the atherosclerotic process, but adaptive immunity, through B and T lymphocytes, as well as dendritic cells, also modulates the progression of the disease. Analysis of the role of different T cell subpopulations in murine models of atherosclerosis identified effector Th1 cells as proatherogenic, whereas regulatory T cells (Tregs) have been shown to protect against atherosclerosis. For these reasons, better understanding of how Tregs influence the atherosclerotic process is believed to provide novel Treg-targeted therapies to combat atherosclerosis. This review article summarizes current knowledge about the role of Tregs in atherosclerosis and discusses ways to enhance their function as novel immunomodulatory therapeutic approaches against cardiovascular disease.
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