Effects of the head-down tilt posture on postnatal development of the aortic baroreflex in the rabbit.
Effects of the head-down tilt posture on postnatal development of the aortic baroreflex in the rabbit.
复制标题
低头倾斜姿势对家兔产后主动脉压力反射发育的影响。
DOI：
10.2170/jjphysiol.52.149
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Tsuyoshi Shimizu
中科院分区：
文献类型：
--
作者：
M. Yamasaki;Tsuyoshi Shimizu
为了阐明头向下倾斜（HDT）姿势对出生后主动脉压力反射发育的影响，我们将3-4周龄的家兔饲养在这种模拟体液在空间中向前移动的姿势下34-36 d，并研究了主动脉神经和压力反射反应的结构和功能特征。将家兔分为3个不同的组：20度HDT组、环境对照组（EC）和体内对照组（VIV）。基底动脉压下左主动脉神经活动（ANA）定义为100%，在动脉压最大升高时，HDT组的最大ANA为265+/-103%（平均+/-SD， n=5）， EC组为482+/-170% (n=4)， VIV组为677+/-491% （n=4）。动脉压最大降低时，HDT组最小ANA为67.3+/-13.8%，EC组为40.1+/-10.2%，VIV组为38.6+/-13.8%。HDT组ANA随最大动脉压变化的最大变化明显小于EC组和VIV组（p<0.05）。HDT组的平均反射增益显著低于VIV组（p<0.05）。HDT组左主动脉神经无髓鞘纤维数量明显少于对照组（p<0.05）。因此，主动脉压力反射系统的发育明显受到HDT姿势的抑制，这表明在太空中发育的哺乳动物也会出现类似的结果。
To clarify the effects of the head-down tilt (HDT) posture on the postnatal development of the aortic baroreflex, we raised rabbits from 3-4 weeks of age for 34-36 d in this posture, which simulates the headward shift of body fluid in space, and examined the structural and functional characteristics of the aortic nerves and baroreflex responses. The rabbits were divided into 3 different groups: 20 degrees HDT, environmental control (EC), and vivarium control (VIV). Left aortic nerve activity (ANA) at basal arterial pressure was defined as 100%, and the maximum ANA at maximal increase in arterial pressure was 265+/-103% (mean+/-SD, n=5) in the HDT, 482+/-170% (n=4) in the EC, and 677+/-491% (n=4) in the VIV groups. The minimum ANA at maximal decrease in arterial pressure was 67.3+/-13.8% in the HDT, 40.1+/-10.2% in the EC, and 38.6+/-13.8% in the VIV groups. The maximal change of ANA in response to maximal change in arterial pressure in the HDT group was significantly less than that of either the EC or VIV group (p<0.05). The average baroreflex gain in the HDT group was significantly less than in the VIV group (p<0.05). The number of unmyelinated fibers in the left aortic nerve in the HDT group was significantly less than that of each control group (p<0.05). Thus the development of the aortic baroreflex system is apparently depressed by the HDT posture, suggesting that similar consequences will be observed in mammals that develop in space.
影响因子：
3.3
作者：
OVERTON, JM;TIPTON, CM
通讯作者：
TIPTON, CM
DOI：
10.1016/0165-3806(94)90163-5
发表时间：
1994-10-14
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
COGGESHALL, RE;POWER, CM;FITZGERALD, M
通讯作者：
FITZGERALD, M
兔和大鼠主动脉压力感受器 C 纤维的激活机制。
DOI：
10.1046/j.1365-201x.1999.00556.x
发表时间：
1999
期刊：
Acta physiologica Scandinavica.
影响因子：
--
作者：
Thoren,P;Munch,PA;Brown,AM
通讯作者：
Brown,AM