Anti-SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms.
Anti-SARS-CoV-2 and Autoantibody Profiles in the Cerebrospinal Fluid of 3 Teenaged Patients With COVID-19 and Subacute Neuropsychiatric Symptoms.
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DOI：
10.1001/jamaneurol.2021.3821
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发表时间：
2021-12-01
期刊：
影响因子：
29
通讯作者：
Wilson MR
中科院分区：
文献类型：
--
作者：
Bartley CM;Johns C;Ngo TT;Dandekar R;Loudermilk RL;Alvarenga BD;Hawes IA;Zamecnik CR;Zorn KC;Alexander JR;Wapniarski AE;DeRisi JL;Francisco C;Nash KB;Wietstock SO;Pleasure SJ;Wilson MR
小儿COVID-19伴神经精神症状患者脑脊液中是否存在抗sars - cov -2或抗神经抗体？在本病例中，3例患有亚急性神经精神障碍的儿童患者中，2例有鞘内抗sars - cov -2抗体和鞘内抗神经抗体。抗转录因子4 （TCF4）自身抗体在一名对免疫治疗有反应的患者中得到验证。一部分患有COVID-19和亚急性神经精神症状的儿童患者鞘内存在抗神经自身抗体，提示患有COVID-19和近期神经精神症状的儿童患者存在中枢神经系统自身免疫。本病例系列研究了小儿COVID-19和亚急性神经精神功能障碍患者的脑脊液中是否存在抗sars - cov -2和自身反应性抗体。在儿科人群中已经报道了COVID-19的神经精神表现。目的：检测小儿COVID-19合并亚急性神经精神功能障碍患者脑脊液中是否存在抗sars - cov -2和自身反应性抗体。本病例系列包括3例近期感染SARS-CoV-2的患者，经逆转录聚合酶链反应或IgG血液学检查证实，近期有暴露史，在加州大学旧金山分校贝尼奥夫儿童医院住院，并于2020年要求在5个月内进行神经病学会诊。在此期间，共有18名儿童住院，并通过逆转录聚合酶链反应或快速抗原试验检测出急性SARS-CoV-2感染阳性。脑脊液抗sars - cov -2 IgG和抗神经抗体的检测与鉴定。在3例纳入的青少年患者中，2例患者鞘内有抗sars - cov -2抗体。解剖免疫染色显示两例患者脑脊液IgG为抗神经自身抗体。针对转录因子4 （TCF4）的自身抗体在1例患者中似乎对免疫治疗有强烈反应，也得到了验证。患有COVID-19和突出的亚急性神经精神症状（从严重焦虑到妄想性精神病）的儿科患者的脑脊液中可能含有抗sars - cov -2和抗神经抗体，并可能对免疫治疗有反应。
Are anti–SARS-CoV-2 or antineural antibodies present in the cerebrospinal fluid of pediatric patients with COVID-19 and neuropsychiatric symptoms? In this case series of 3 pediatric patients with subacute neuropsychiatric impairment, 2 had intrathecal anti–SARS-CoV-2 antibodies as well as intrathecal antineural antibodies. Anti–transcription factor 4 (TCF4) autoantibodies in one patient who responded to immunotherapy were validated. A subset of pediatric patients with COVID-19 and subacute neuropsychiatric symptoms have intrathecal antineural autoantibodies, suggesting central nervous system autoimmunity in pediatric patients with COVID-19 and recent neuropsychiatric symptoms. This case series examines whether anti–SARS-CoV-2 and autoreactive antibodies are present in the cerebrospinal fluid (CSF) of pediatric patients with COVID-19 and subacute neuropsychiatric dysfunction. Neuropsychiatric manifestations of COVID-19 have been reported in the pediatric population. To determine whether anti–SARS-CoV-2 and autoreactive antibodies are present in the cerebrospinal fluid (CSF) of pediatric patients with COVID-19 and subacute neuropsychiatric dysfunction. This case series includes 3 patients with recent SARS-CoV-2 infection as confirmed by reverse transcriptase–polymerase chain reaction or IgG serology with recent exposure history who were hospitalized at the University of California, San Francisco Benioff Children’s Hospital and for whom a neurology consultation was requested over a 5-month period in 2020. During this period, 18 total children were hospitalized and tested positive for acute SARS-CoV-2 infection by reverse transcriptase–polymerase chain reaction or rapid antigen test. Detection and characterization of CSF anti–SARS-CoV-2 IgG and antineural antibodies. Of 3 included teenaged patients, 2 patients had intrathecal anti–SARS-CoV-2 antibodies. CSF IgG from these 2 patients also indicated antineural autoantibodies on anatomic immunostaining. Autoantibodies targeting transcription factor 4 (TCF4) in 1 patient who appeared to have a robust response to immunotherapy were also validated. Pediatric patients with COVID-19 and prominent subacute neuropsychiatric symptoms, ranging from severe anxiety to delusional psychosis, may have anti–SARS-CoV-2 and antineural antibodies in their CSF and may respond to immunotherapy.
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DOI：
10.1016/j.xcrm.2020.100123
发表时间：
2020-10-20
期刊：
Cell reports. Medicine
影响因子：
--
作者：
Zamecnik CR;Rajan JV;Yamauchi KA;Mann SA;Loudermilk RP;Sowa GM;Zorn KC;Alvarenga BD;Gaebler C;Caskey M;Stone M;Norris PJ;Gu W;Chiu CY;Ng D;Byrnes JR;Zhou XX;Wells JA;Robbiani DF;Nussenzweig MC;DeRisi JL;Wilson MR
通讯作者：
Wilson MR
DOI：
10.1016/s2215-0366(20)30462-4
发表时间：
2021-03
期刊：
The lancet. Psychiatry
影响因子：
--
作者：
Taquet M;Luciano S;Geddes JR;Harrison PJ
通讯作者：
Harrison PJ
影响因子：
3.7
作者：
Miao W;Man F;Wu S;Lv B;Wang Z;Xian J;Sabel BA;He H;Jiao Y
通讯作者：
Jiao Y
影响因子：
6.8
作者：
Teixeira JR;Szeto RA;Carvalho VMA;Muotri AR;Papes F
通讯作者：
Papes F
DOI：
10.1212/nxi.0000000000000893
发表时间：
2020-11
期刊：
Neurology(R) neuroimmunology & neuroinflammation
影响因子：
--
作者：
Alexopoulos H;Magira E;Bitzogli K;Kafasi N;Vlachoyiannopoulos P;Tzioufas A;Kotanidou A;Dalakas MC
通讯作者：
Dalakas MC