Tailored near-infrared contrast agents for image guided surgery.
Tailored near-infrared contrast agents for image guided surgery.
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DOI：
10.1021/acs.jmedchem.5b00253
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发表时间：
2015-03-26
影响因子：
7.3
通讯作者：
Henary, Maged
中科院分区：
文献类型：
--
作者：
Njiojob, Costyl N.;Owens, Eric A.;Narayana, Lakshminarayana;Hyun, Hoon;Choi, Hak Soo;Henary, Maged
近红外(NIR)荧光能否成功地用于术中成像取决于能否开发出一种高度稳定、无毒、生物相容性和高排泄性的化合物，该化合物保留了与癌症识别多肽偶联的反应功能。在此，探索了对先前详细的荧光团ZW800-1的系统修饰。具体的修饰，包括ZW800-1的O原子的等位取代，包括连接到七甲基核的亲核胺和硫物种。这些新化合物在生物分布和清除性方面表现出相似的令人满意的结果，同时也在血清中表现出更高的稳定性。最重要的是，所有合成和评价的化合物都显示出可进一步生物偶联的反应性官能团(游离氨基或羧酸部分)。从新制备的衍生物得到的结果表明，与所研究的连接剂的中心取代保持了荧光团在体内的超低背景性能，而与总净电荷无关。
The success of near-infrared (NIR) fluorescence to be employed for intraoperative imaging relies on the ability to develop a highly stable, NIR fluorescent, nontoxic, biocompatible, and highly excreted compound that retains a reactive functionality for conjugation to a cancer-recognizing peptide. Herein, systematic modifications to previously detailed fluorophore ZW800-1 are explored. Specific modifications, including the isosteric replacement of the O atom of ZW800-1, include nucleophilic amine and sulfur species attached to the heptamethine core. These novel compounds have shown similar satisfactory results in biodistribution and clearance while also expressing increased stability in serum. Most importantly, all of the synthesized and evaluated compounds display a reactive functionality (either a free amino group or carboxylic acid moiety) for further bioconjugation. The results obtained from the newly prepared derivatives demonstrate that the central substitution with the studied linking agents retains the ultralow background in vivo performance of the fluorophores regardless of the total net charge.
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影响因子：
62.1
作者：
Kobayashi, Hisataka;Ogawa, Mikako;Alford, Raphael;Choyke, Peter L.;Urano, Yasuteru
通讯作者：
Urano, Yasuteru
影响因子：
3.6
作者：
Lee, Hyeran;Mason, J. Christian;Achilefu, Samuel
通讯作者：
Achilefu, Samuel
影响因子：
4.3
作者：
Ornelas, Catia;Lodescar, Rachelle;Weck, Marcus
通讯作者：
Weck, Marcus
影响因子：
4.7
作者：
Flanagan, JH;Khan, SH;Hammer, RP
通讯作者：
Hammer, RP
影响因子：
16.6
作者：
Achilefu, Samuel
通讯作者：
Achilefu, Samuel