Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.
Local triple-combination therapy results in tumour regression and prevents recurrence in a colon cancer model.
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DOI：
10.1038/nmat4707
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发表时间：
2016-10
期刊：
影响因子：
41.2
通讯作者：
Artzi N
中科院分区：
文献类型：
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作者：
Conde J;Oliva N;Zhang Y;Artzi N
常规的癌症疗法涉及抗癌剂的全身递送，这些抗癌剂既不区分癌症和正常细胞，也不消除癌症复发的风险。在这里，我们证明了通过预防性水凝胶贴片在结肠癌小鼠模型中通过预防性水凝胶贴剂提供的基因，药物和光疗的组合，当将肿瘤施加到非分离的肿瘤上时，在肿瘤复发中施用时，在肿瘤复发中完全缓解了肿瘤。切除。粘合水凝胶贴片增强了稳定性，并提供了嵌入式纳米颗粒的局部递送。球形金纳米颗粒被用作第一波治疗浪潮，以对Kras（Kras）发射siRNA，这是一个关键的癌基因驱动器，杆状的金纳米颗粒介导了近红外辐射转化为热量，从而释放了化学疗法以及热诱导细胞损伤。这种局部三合一疗法可以适应其他癌细胞类型和与疾病进展相关的分子靶标。
Conventional cancer therapies involve the systemic delivery of anticancer agents that neither discriminate between cancer and normal cells nor eliminate the risk of cancer recurrence. Here, we demonstrate that the combination of gene, drug and phototherapy delivered through a prophylactic hydrogel patch leads, in a colon cancer mouse model, to complete tumour remission when applied to non-resected tumours and to the absence of tumour recurrence when applied following tumour resection. The adhesive hydrogel patch enhanced the stability and provided local delivery of embedded nanoparticles. Spherical gold nanoparticles were used as a first wave of treatment to deliver siRNAs against Kras, a key oncogene driver, and rod-shaped gold nanoparticles mediated the conversion of near-infrared radiation into heat, causing the release of a chemotherapeutic as well as thermally induced cell damage. This local, triple-combination therapy can be adapted to other cancer cell types and to molecular targets associated with disease progression.
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影响因子：
64.8
作者：
Lu, J;Getz, G;Golub, TR
通讯作者：
Golub, TR
影响因子：
4.2
作者：
Kok-Sin T;Mokhtar NM;Ali Hassan NZ;Sagap I;Mohamed Rose I;Harun R;Jamal R
通讯作者：
Jamal R
影响因子：
41.2
作者：
Conde J;Oliva N;Atilano M;Song HS;Artzi N
通讯作者：
Artzi N
DOI：
10.1021/la303155p
发表时间：
2012-10-30
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
Oliva N;Shitreet S;Abraham E;Stanley B;Edelman ER;Artzi N
通讯作者：
Artzi N
影响因子：
41.2
作者：
通讯作者：
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