Roles of TRAFs in Ischemia-Reperfusion Injury.
Roles of TRAFs in Ischemia-Reperfusion Injury.
复制标题
TRAF 在缺血再灌注损伤中的作用
DOI：
10.3389/fcell.2020.586487
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Ye Q
中科院分区：
文献类型：
--
作者：
Zhou W;Lin D;Zhong Z;Ye Q
Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAF-dependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.
登录
查看更多内容
影响因子：
3.3
作者：
Chen, Yen-Ta;Yang, Chih-Chao;Yip, Hon-Kan
通讯作者：
Yip, Hon-Kan
MAVS 通过 TRAF 以 NEMO 依赖和独立方式激活 TBK1 和 IKKε
影响因子：
6.7
作者：
Fang R;Jiang Q;Zhou X;Wang C;Guan Y;Tao J;Xi J;Feng JM;Jiang Z
通讯作者：
Jiang Z
肢体远程缺血后处理通过抑制中性粒细胞 NADPH 氧化酶激活和 MyD88-TRAF6-P38MAP-激酶途径减少缺血再灌注损伤
影响因子：
5.6
作者：
Chen, Gangling;Ye, Xinyi;Kou, Junping
通讯作者：
Kou, Junping
鸢尾素在肺缺血/再灌注损伤期间保护线粒体功能。
影响因子：
17.1
作者：
Chen K;Xu Z;Liu Y;Wang Z;Li Y;Xu X;Chen C;Xia T;Liao Q;Yao Y;Zeng C;He D;Yang Y;Tan T;Yi J;Zhou J;Zhu H;Ma J;Zeng C
通讯作者：
Zeng C
DOI：
10.1126/science.1233009
发表时间：
2013-03-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Clark VE;Erson-Omay EZ;Serin A;Yin J;Cotney J;Ozduman K;Avşar T;Li J;Murray PB;Henegariu O;Yilmaz S;Günel JM;Carrión-Grant G;Yilmaz B;Grady C;Tanrikulu B;Bakircioğlu M;Kaymakçalan H;Caglayan AO;Sencar L;Ceyhun E;Atik AF;Bayri Y;Bai H;Kolb LE;Hebert RM;Omay SB;Mishra-Gorur K;Choi M;Overton JD;Holland EC;Mane S;State MW;Bilgüvar K;Baehring JM;Gutin PH;Piepmeier JM;Vortmeyer A;Brennan CW;Pamir MN;Kiliç T;Lifton RP;Noonan JP;Yasuno K;Günel M
通讯作者：
Günel M