Translation drives mRNA quality control.

Translation drives mRNA quality control.
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DOI:
10.1038/nsmb.2301
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发表时间:
2012-06-05
影响因子:
16.8
通讯作者:
Green, Rachel
Green, Rachel
中科院分区:
生物学1区
文献类型:
--
作者:
Shoemaker, Christopher J.;Green, Rachel

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共翻译的mRNA监测有三种主要形式:无意义介导的衰变(NMD)、不进行的衰变(NGD)和不停止的衰变(NSD)。虽然对这些途径的讨论往往集中在mRNA的命运上,但越来越多的人达成共识,认为这些过程还有其他重要的结果必须同时考虑。在这里,我们试图强调NMD、NGD和NSD之间的相似之处以及它们在翻译过程中可能起源于核糖体。
There are three predominant forms of co-translational mRNA surveillance: nonsense-mediated decay (NMD), no-go decay (NGD) and non-stop decay (NSD). While discussion of these pathways often focuses on mRNA fate, there is growing consensus that there are other important outcomes of these processes that must be simultaneously considered. Here, we seek to highlight similarities between NMD, NGD and NSD and their likely origins on the ribosome during translation.
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