Significance of apoptotic cell death in systemic complications with severe acute pancreatitis.
Significance of apoptotic cell death in systemic complications with severe acute pancreatitis.
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DOI：
10.1007/s00535-004-1505-8
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发表时间：
2005-01
影响因子：
6.3
通讯作者：
Takeyama Y
中科院分区：
文献类型：
--
作者：
Takeyama Y
在重症急性胰腺炎中，由于胰腺或胰周失活组织感染，发病后早期多器官功能衰竭，晚期脓毒症，导致其高死亡率。与脓毒症类似，越来越多的证据表明凋亡细胞死亡在急性胰腺炎相关的全身表现中具有重要意义。自从1995年我们在胰腺炎相关腹水中发现了凋亡诱导活性以来，包括我们小组在内的许多研究者通过动物实验报道了在构成器官的实质细胞中发生凋亡，如肺中的肺泡上皮细胞、肾中的肾小管细胞和肝中的肝细胞，这种凋亡参与了重症急性胰腺炎的器官功能障碍。此外，通过临床和实验研究，细胞凋亡已被揭示参与急性胰腺炎感染并发症的机制。也就是说，淋巴组织和外周循环淋巴细胞中的细胞凋亡参与细胞免疫的损害，并且肠上皮细胞中的细胞凋亡涉及细菌移位。这些结果表明，凋亡细胞死亡可能在影响重症急性胰腺炎的死亡率和发病率方面发挥了相当大的作用。控制细胞凋亡可能是改善重症急性胰腺炎临床结局的有效策略。
In severe acute pancreatitis, multiple organ failure in the early stage after onset, and sepsis in the late stage, due to infection of pancreatic or peripancreatic devitalized tissue, contribute to its high mortality. In analogy with sepsis, evidence has accumulated of the significance of apoptotic cell death in the systemic manifestations associated with acute pancreatitis. Since we identified apoptosis-inducing activity in pancreatitis-associated ascitic fluid in 1995, a number of investigators, including our group, have reported, through animal experiments, that apoptosis occurred in the parenchymal cells constituting organs, such as alveolar epithelial cells in the lung, renal tubular cells in the kidney, and hepatocytes in the liver, and this apoptosis was involved in organ dysfunction with severe acute pancreatitis. Moreover, through clinical and experimental investigations, apoptosis has been revealed to be involved in the mechanism of infectious complications in acute pancreatitis. Namely, apoptosis in lymphatic tissues and peripherally circulating lymphocytes is involved in the impairment of cellular immunity, and apoptosis in gut epithelial cells is implicated in bacterial translocation. These results suggest that apoptotic cell death may play a considerable role in affecting mortality and morbidity in severe acute pancreatitis. Control of apoptosis could be a potent strategy for improvement of the clinical outcome in severe acute pancreatitis.
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影响因子：
3.7
作者：
ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
通讯作者：
NICOTERA, P
影响因子：
4.7
作者：
BURSCH, W;LAUER, B;SCHULTEHERMANN, R
通讯作者：
SCHULTEHERMANN, R
影响因子：
--
作者：
Hotchkiss, RS;Tinsley, KW;Karl, IE
通讯作者：
Karl, IE
DOI：
10.1016/s1521-6918(03)00073-8
发表时间：
2003-10-01
影响因子：
3.2
作者：
Bengmark, S
通讯作者：
Bengmark, S
影响因子：
3.8
作者：
Callicutt, CS;Sabek, O;Gaber, AO
通讯作者：
Gaber, AO