Metabolomic differences between critically Ill women and men.
Metabolomic differences between critically Ill women and men.
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DOI：
10.1038/s41598-021-83602-5
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发表时间：
2021-02-17
影响因子：
4.6
通讯作者：
Christopher KB
中科院分区：
文献类型：
--
作者：
Chary S;Amrein K;Lasky-Su JA;Dobnig H;Christopher KB
在体内平衡方面，女性和男性的代谢是不同的。危重病人体内平衡和新陈代谢严重失调。目前尚不清楚女性与男性相比对危重疾病的代谢反应是否不同。这种疾病反应的性别特异性差异将对个性化医疗产生影响。我们的目的是确定性别特异性代谢组学反应的早期危重病。我们对VITdAL-ICU试验进行了事后代谢组学研究，受试者接受高剂量维生素D3或安慰剂。使用混合效应模型，我们研究了性别特异性代谢物随时间的变化，调整了年龄，简化急性生理学评分II，入院诊断，第0天25-羟基维生素D水平和25-羟基维生素D对干预的反应。在女性中，与男性相比，鞘磷脂和溶血磷脂代谢物类的多个成员随时间推移具有显著的正Bonferroni校正关联。此外，与男性相比，酰基肉毒碱、雄激素类固醇、胆汁酸、核苷酸和氨基酸代谢物类别的多个代表随时间推移具有显著负的Bonferroni校正关联。高斯图形模型分析显示性别特异性功能模块。我们的研究结果表明，在危重病的早期存在强大和协调的性别特异性代谢物差异。
Metabolism differs in women and men at homeostasis. Critically ill patients have profound dysregulation of homeostasis and metabolism. It is not clear if the metabolic response to critical illness differs in women compared to men. Such sex-specific differences in illness response would have consequences for personalized medicine. Our aim was to determine the sex-specific metabolomic response to early critical illness. We performed a post-hoc metabolomics study of the VITdAL-ICU trial where subjects received high dose vitamin D3 or placebo. Using mixed-effects modeling, we studied sex-specific changes in metabolites over time adjusted for age, Simplified Acute Physiology Score II, admission diagnosis, day 0 25-hydroxyvitamin D level, and 25-hydroxyvitamin D response to intervention. In women, multiple members of the sphingomyelin and lysophospholipid metabolite classes had significantly positive Bonferroni corrected associations over time compared to men. Further, multiple representatives of the acylcarnitine, androgenic steroid, bile acid, nucleotide and amino acid metabolite classes had significantly negative Bonferroni corrected associations over time compared to men. Gaussian graphical model analyses revealed sex-specific functional modules. Our findings show that robust and coordinated sex-specific metabolite differences exist early in critical illness.
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影响因子：
5
作者：
Gaskins, Audrey J.;Wilchesky, Machelle;Schisterman, Enrique F.
通讯作者：
Schisterman, Enrique F.
影响因子：
--
作者：
Krumsiek J;Suhre K;Illig T;Adamski J;Theis FJ
通讯作者：
Theis FJ
影响因子：
4
作者：
Do KT;Pietzner M;Rasp DJ;Friedrich N;Nauck M;Kocher T;Suhre K;Mook-Kanamori DO;Kastenmüller G;Krumsiek J
通讯作者：
Krumsiek J
影响因子：
3.6
作者：
Dunn, Warwick B.;Lin, Wanchang;Broadhurst, David;Begley, Paul;Brown, Marie;Zelena, Eva;Vaughan, Andrew A.;Halsall, Antony;Harding, Nadine;Knowles, Joshua D.;Francis-McIntyre, Sue;Tseng, Andy;Ellis, David I.;O'Hagan, Steve;Aarons, Gill;Benjamin, Boben;Chew-Graham, Stephen;Moseley, Carly;Potter, Paula;Winder, Catherine L.;Potts, Catherine;Thornton, Paula;McWhirter, Catriona;Zubair, Mohammed;Pan, Martin;Burns, Alistair;Cruickshank, J. Kennedy;Jayson, Gordon C.;Purandare, Nitin;Wu, Frederick C. W.;Finn, Joe D.;Haselden, John N.;Nicholls, Andrew W.;Wilson, Ian D.;Goodacre, Royston;Kell, Douglas B.
通讯作者：
Kell, Douglas B.
影响因子：
3.6
作者：
Kelly, Rachel S.;Croteau-Chonka, Damien C.;Lasky-Su, Jessica A.
通讯作者：
Lasky-Su, Jessica A.