NPY alterations induced by chronic morphine exposure affect the maintenance and reinstatement of morphine conditioned place preference
NPY alterations induced by chronic morphine exposure affect the maintenance and reinstatement of morphine conditioned place preference
复制标题
慢性吗啡暴露引起的 NPY 改变会影响吗啡条件性位置偏好的维持和恢复。
DOI：
10.1016/j.neuropharm.2020.108350
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发表时间：
2020-10
影响因子：
4.7
通讯作者：
Songtao Qi
中科院分区：
文献类型：
--
作者：
Xingqin Wang;Zhen Tian;Jie Ma;Zhanpeng Feng;Yichao Ou;Mingfeng Zhou;Junjie Peng;Yunfei Lv;Guodong Gao;Songtao Qi
阿片类药物成瘾是一种严重危害社会和个人健康的脑部疾病。尽管全球范围内阿片类药物成瘾的患者数量巨大，并出现了不良事件，但目前仍缺乏有效的治疗方法。神经肽Y（neuropeptide Y，NPY）是一种重要的促食欲肽，在食物摄取和能量代谢中起重要作用。然而，越来越多的证据表明，NPY可能在介导奖赏效应和药物依赖方面具有巨大的潜力。在本研究中，我们评估了在吗啡条件性位置偏爱（CPP）后的不同时间点，在延髓核中的NPY的表达变化，并探讨潜在的NPY变化的功能意义。我们的研究结果表明，NPY的表达显着下降后，立即慢性吗啡暴露在延髓核壳（AcbSh）。随后，它开始迅速增加，然后逐渐恢复到正常水平。进一步的数据表明，这些NPY的变化涉及吗啡奖赏记忆，表现为在AcbSh中用L-152，804阻断Y 5受体后消退期缩短，以及在应用NPY后消退期持续时间延长。更重要的是，额外的结果表明，L-152，804也显着抑制吗啡CPP的恢复。总之，我们的研究结果表明，一个复杂的可塑性神经肽Y通路在AcbSh发生后吗啡CPP，这种可塑性在调节吗啡奖赏记忆中起着重要的作用。这些发现可能会增强我们对阿片成瘾中NPY系统作用的理解，并为阿片成瘾治疗提供一个有希望的靶点。
Opioid addiction is a brain disease that severely harms society and personal health. Although the tremendous numbers of patients worldwide and emerged negative events, effective treatments for opioid addiction are still lacking. Neuropeptide Y (NPY) is one of the main orexigenic peptides that play vital roles in food intake and energy metabolism. However, increasing evidence indicates that NPY may have great potential in mediating reward effects and drug dependence. In the present study, we assessed the expression changes of NPY in the nucleus accumbens at different timepoints following morphine conditioned place preference (CPP) and investigated the functional importance of potential NPY changes. Our results showed that NPY expression significantly decreased in the nucleus accumbens shell (AcbSh) immediately after chronic morphine exposure. Subsequently, it increased rapidly at first and then gradually returned to normal levels. Further data indicated that these NPY changes were involved in morphine reward memory, demonstrated by a reduction in the extinction period after blocking of the Y5 receptor by L-152,804 in the AcbSh and a prolonged duration of the extinction period following the application of NPY. More importantly, the additional results revealed that L-152,804 also remarkably suppressed the reinstatement of morphine CPP. Together, our results indicate that a complicated plasticity of the NPY pathway in AcbSh occurs following morphine CPP, and this plasticity plays an important role in modulating morphine reward memory. These findings may enhance our understanding of the role of the NPY system in opioid addiction and indicate a promising target for opioid addiction treatment.
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影响因子：
--
作者：
BILLINGTON, CJ;BRIGGS, JE;LEVINE, AS
通讯作者：
LEVINE, AS
吗啡依赖性和戒断期间，大鼠下丘脑中应激和代谢相关的神经肽表达的差异变化。
影响因子：
3.7
作者：
Pintér-Kübler B;Ferenczi S;Núnez C;Zelei E;Polyák A;Milanés MV;Kovács KJ
通讯作者：
Kovács KJ
影响因子：
3.4
作者：
Tia Maric;F. Sedki;Danielle Chafetz;Nick Schoela;U. Shalev
通讯作者：
Tia Maric;F. Sedki;Danielle Chafetz;Nick Schoela;U. Shalev
影响因子：
5.2
作者：
Thorsell A;Mathé AA
通讯作者：
Mathé AA
影响因子：
4.8
作者：
K. Skibicka;Rozita H. Shirazi;C. Hansson;S. Dickson
通讯作者：
K. Skibicka;Rozita H. Shirazi;C. Hansson;S. Dickson