Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System.
Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System.
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DOI：
10.3389/fimmu.2020.566892
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发表时间：
2020
影响因子：
7.3
通讯作者：
Tomlinson S
中科院分区：
文献类型：
--
作者：
Borucki DM;Toutonji A;Couch C;Mallah K;Rohrer B;Tomlinson S
这篇综述的重点是补体介导的吞噬作用在影响视觉系统的视网膜和神经系统疾病中的作用。补体激活产物调理神经元上的突触物质以用于吞噬去除，这是发育期间的正常生理过程，但在几种神经退行性疾病和病症中是病理过程。我们讨论的作用，补体在细化和消除突触的视网膜和外侧膝状体核，无论是在发展和疾病状态。补体和异常吞噬作用如何促进视觉系统损伤主要在多发性硬化症的背景下讨论，在那里它已被广泛研究，尽管补体在其他疾病如中风和创伤性脑损伤中的视觉功能障碍中的作用也被强调。视网膜疾病也包括在内，重点是青光眼和老年性黄斑变性。最后，我们讨论了补体抑制策略治疗影响视觉系统的疾病的潜力。
The focus of this review is the role of complement-mediated phagocytosis in retinal and neurological diseases affecting the visual system. Complement activation products opsonize synaptic material on neurons for phagocytic removal, which is a normal physiological process during development, but a pathological process in several neurodegenerative diseases and conditions. We discuss the role of complement in the refinement and elimination of synapses in the retina and lateral geniculate nucleus, both during development and in disease states. How complement and aberrant phagocytosis promotes injury to the visual system is discussed primarily in the context of multiple sclerosis, where it has been extensively studied, although the role of complement in visual dysfunction in other diseases such as stroke and traumatic brain injury is also highlighted. Retinal diseases are also covered, with a focus on glaucoma and age-related macular degeneration. Finally, we discuss the potential of complement inhibitory strategies to treat diseases affecting the visual system.
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影响因子：
3.4
作者：
Magnin E;Chamard L;Vuillier F;Tatu L;Berger E
通讯作者：
Berger E
影响因子：
3
作者：
Annamalai B;Parsons N;Belhaj M;Brandon C;Potts J;Rohrer B
通讯作者：
Rohrer B
影响因子：
5.3
作者：
Alawieh, Ali M.;Langley, E. Farris;Tomlinson, Stephen
通讯作者：
Tomlinson, Stephen
影响因子：
4.4
作者：
Collier, Robert J.;Wang, Yu;Romano, Carmelo
通讯作者：
Romano, Carmelo
影响因子：
4.2
作者：
Bellander, BM;Singhrao, SK;Svensson, M
通讯作者：
Svensson, M