Lipid mediators and allergic diseases.
Lipid mediators and allergic diseases.
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DOI：
10.1016/j.anai.2013.06.031
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发表时间：
2013-09
影响因子：
5.9
通讯作者：
Boyce, Joshua A.
中科院分区：
文献类型：
--
作者：
Fanning, Laura B.;Boyce, Joshua A.
脂质是主要的营养能量来源，也是所有生物细胞膜的主要成分。脂质分子还可以在细胞间信号传导中起作用，并且在炎症和免疫应答中以及在许多正常细胞功能和稳态的调节中具有重要作用。前列腺素（PG）、白三烯（LT）和具有这种信号传导作用的各种其它脂质分子被称为脂质介质或生物活性脂质。这些分子由前体膜脂质按需合成，主要通过与G蛋白偶联受体（GPCRs）1结合发挥作用。脂质介质作为过敏性疾病的诊断标志物和治疗靶点的重要性早已被认识到并继续发展。哮喘尤其如此，关于哮喘，在过敏性疾病中有最大和最广泛的已发表文献。在这篇综述中，我们将提供一个概述的途径脂质介质的产生，并检查特定的脂质介质的过敏性炎症的病理生物学的相关性，以及对当前和未来的过敏性疾病的临床管理的影响。尽管溶血磷脂、脂氧素和其他脂质与过敏性炎症的机制有关，但由于现有文献（包括临床数据）中关于这些介质的大量资料，我们将重点关注PG和LT。本综述中讨论的介质总结见表1。
Lipids are a primary nutrient energy source as well as major components of the cell membranes of all organisms. Lipid molecules can also function in intercellular signaling and have important roles in inflammatory and immune responses, as well as in regulation of many normal cellular functions and homeostasis. Prostaglandins (PGs), leukotrienes (LTs), and a variety of other lipid molecules with such signaling roles are known as lipid mediators or bioactive lipids. These molecules are synthesized on-demand from precursor membrane lipids and act primarily by binding to G protein-coupled receptors (GPCRs) 1.The importance of lipid mediators as both diagnostic markers and therapeutic targets in allergic diseases has been long recognized and continues to evolve. This is particularly true of asthma, regarding which there is the largest and broadest body of published literature among the allergic diseases. In this review, we will provide an overview of the pathways of lipid mediator generation and examine the relevance of specific lipid mediators to the pathobiology of allergic inflammation as well as implications for current and future clinical management of allergic diseases. Although lysophospholipids, lipoxins, and other lipids are relevant to the mechanisms of allergic inflammation, we will focus on PGs and LTs because of the abundance of existing literature, including clinical data, regarding these mediators. A summary of the mediators discussed in this review can be found in Table 1.
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DOI：
10.1084/jem.184.4.1483
发表时间：
1996-10-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1084/jem.20100793
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barrett NA;Rahman OM;Fernandez JM;Parsons MW;Xing W;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
影响因子：
4
作者：
Brock, TG
通讯作者：
Brock, TG
DOI：
10.4049/jimmunol.1201865
发表时间：
2012-11-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Barrett NA;Fernandez JM;Maekawa A;Xing W;Li L;Parsons MW;Austen KF;Kanaoka Y
通讯作者：
Kanaoka Y
影响因子：
4.4
作者：
Fujitani, Y;Kanaoka, Y;Urade, Y
通讯作者：
Urade, Y