The regulation of totipotency transcription: Perspective from in vitro and in vivo totipotency.
The regulation of totipotency transcription: Perspective from in vitro and in vivo totipotency.
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全能性转录的调控：体外和体内全能性的视角
DOI：
10.3389/fcell.2022.1024093
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
全能性代表最高的发育潜能。根据定义，全能干细胞能够产生所有胚胎和胚外细胞类型。在哺乳动物胚胎中，全能性发生在合子基因组激活期附近，其在小鼠胚胎中为2细胞期或在人胚胎中为4- 8细胞期。目前，随着体外全能样模型的发展和小规模基因组学方法的进步，能够对全能性状态和调控进行深入的机制理解。本文从遗传学和表观遗传学的角度对全能性的研究现状进行了综述。这将有希望制定一个全景全能性从现有的研究工作，直到现在。它还可以帮助描绘支架和制定新的全能性假说，为未来的研究工作。
Totipotency represents the highest developmental potency. By definition, totipotent stem cells are capable of giving rise to all embryonic and extraembryonic cell types. In mammalian embryos, totipotency occurs around the zygotic genome activation period, which is around the 2-cell stage in mouse embryo or the 4-to 8-cell stage in human embryo. Currently, with the development of in vitro totipotent-like models and the advances in small-scale genomic methods, an in-depth mechanistic understanding of the totipotency state and regulation was enabled. In this review, we explored and summarized the current views about totipotency from various angles, including genetic and epigenetic aspects. This will hopefully formulate a panoramic view of totipotency from the available research works until now. It can also help delineate the scaffold and formulate new hypotheses on totipotency for future research works.
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影响因子：
11.8
作者：
Cubenas-Potts, Caelin;Matunis, Michael J.
通讯作者：
Matunis, Michael J.
DOI：
10.1126/science.aag1927
发表时间：
2017-02-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Choi YJ;Lin CP;Risso D;Chen S;Kim TA;Tan MH;Li JB;Wu Y;Chen C;Xuan Z;Macfarlan T;Peng W;Lloyd KC;Kim SY;Speed TP;He L
通讯作者：
He L
影响因子：
23.9
作者：
Cossec, Jack-Christophe;Theurillat, Ilan;Dejean, Anne
通讯作者：
Dejean, Anne
影响因子：
7.7
作者：
De Iaco, Alberto;Coudray, Alexandre;Trono, Didier
通讯作者：
Trono, Didier
影响因子：
64.8
作者：
Chelmicki, Tomasz;Roger, Emeline;Bourc'his, Deborah
通讯作者：
Bourc'his, Deborah