SUMO: a multifaceted modifier of chromatin structure and function.
SUMO: a multifaceted modifier of chromatin structure and function.
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DOI:
10.1016/j.devcel.2012.11.020
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发表时间:
2013-01-14
影响因子:
11.8
通讯作者:
Matunis, Michael J.
中科院分区:
文献类型:
--
作者:
Cubenas-Potts, Caelin;Matunis, Michael J.
A major challenge in nuclear organization is the packaging of DNA into dynamic chromatin structures that can respond to changes in the transcriptional requirements of the cell. Posttranslational protein modifications, of histones and other chromatin-associated factors, are essential regulators of chromatin dynamics. In this review, we summarize studies demonstrating that posttranslational modification of proteins by small ubiquitin-related modifiers (SUMOs) regulates chromatin structure and function at multiple levels and through a variety of mechanisms to influence gene expression and maintain genome integrity.
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期刊:
Human reproduction (Oxford, England)
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