Increased numbers of ion channels promoted by an intracellular second messenger.
Increased numbers of ion channels promoted by an intracellular second messenger.
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细胞内第二信使促进离子通道数量增加。
DOI：
10.1126/science.2432659
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Gunning,R
中科院分区：
文献类型：
--
作者：
Gunning,R
本文研究了腺苷酸介导的5-羟色胺引起的腺苷酸离子异常整流钾电流的直接原因。在电压钳下测量应用5-羟色胺前后的电压依赖性铯离子阻滞和稳态电流功率谱密度。5-羟色胺使异常整流电导的幅值增加，但电导-电压曲线的形状和功率谱没有改变。计算的功能通道的数量和单通道电导的功率谱表明，在电导的增加导致的功能通道的数量增加，而单通道电导和开放通道的概率不变。
The anomalous rectifier potassium current inAplysianeurons was examined to determine the immediate cause of an increase in conductance induced by serotonin and mediated by adenosine 3′,5′-monophosphate. Voltage-dependent cesium ion block and steady-state current power spectral density were measured under voltage clamp before and after application of serotonin. The amplitude of the anomalous rectifier conductance was increased by adding serotonin, but the shapes of the conductance-voltage curve and the power spectrum were not altered. Calculation of the number of functional channels and of the single-channel conductance from the power spectra indicates that the serotonin-induced increase in conductance resulted from an increase in the number of functional channels, while the single-channel conductance and the open-channel probability were unchanged.
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DOI：
10.1073/pnas.79.12.3877
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ADAMS, WB;LEVITAN, IB
通讯作者：
LEVITAN, IB
影响因子：
3.4
作者：
STEVENS, CF
通讯作者：
STEVENS, CF
影响因子：
64.8
作者：
Y. Fukushima
通讯作者：
Y. Fukushima
环核苷酸和肽因子改变软体动物神经元的电活动
影响因子：
64.8
作者：
S. Treistman;I. Levitan
通讯作者：
I. Levitan
影响因子：
2.4
作者：
HAGIWARA, S;TAKAHASHI, K
通讯作者：
TAKAHASHI, K