Psychological and Behavioural Effects of Endogenous Testosterone Levels and Anabolic-Androgenic Steroids Among Males
Psychological and Behavioural Effects of Endogenous Testosterone Levels and Anabolic-Androgenic Steroids Among Males
复制标题
男性内源性睾酮水平和合成代谢雄激素类固醇的心理和行为影响
作者：
M. Bahrke;C. Yesalis;J. Wright
内源性睾酮水平和合成代谢雄激素类固醇在男性中的心理和行为效应已经在临床和非医学用途中研究了50多年，包括合成代谢雄激素类固醇对神经系统和神经肌肉表达的影响，作为行为和ergogenic效应的机制。情绪，行为和内源性血浆睾酮水平，以及合成代谢类固醇和皮质类固醇管理之间的关系进行了研究，包括心理依赖，戒断效应，和主要的方法学问题。虽然在各种动物物种中观察到内源性睾酮水平和攻击行为之间的关系，但在人类中不太一致。可以得出结论，尽管使用外源性合成代谢-雄激素类固醇可能对某些患者和运动员产生心理和行为影响，但这种影响是可变的，停药后是短暂的，似乎与所用合成代谢-雄激素类固醇的类型（17α-碱化而不是17β-酯化）有关，而与剂量无关。遗传因素、病史、环境和同伴影响以及个人期望的作用同样不清楚。总的来说，目前的证据是有限的，为了全面了解这种关系，还需要进行更多的研究。
SummaryThe psychological and behavioural effects of endogenous testosterone levels and anabolic-androgenic steroids in males have been investigated for over 50 years in both clinical and nonmedical uses, including the influence of anabolic-androgenic steroids on the nervous system and neuromuscular expression as a mechanism for behavioural and ergogenic effects. The relationship between moods, behaviour and endogenous plasma testosterone levels, as well as anabolic steroids and corticosteroid administration has been studied, including psychological dependence, withdrawal effects, and major methodological issues. While a relationship between endogenous testosterone levels and aggressive behaviour has been observed in various animal species, it is less consistent in humans. It can be concluded that, although the use of exogenous anabolic-androgenic steroids may have psychological and behavioural effects in some patients and athletes, the effects are variable, transient upon discontinuation of the drugs, and appear to be related to type (17α-alkalated rather than 17β-esterified), but not dose, of anabolic-androgenic steroids administered. The roles of genetic factors, medical history, environmental and peer influences, and individual expectations are likewise unclear. In general, the evidence at present is limited and much additional research will be necessary for a complete understanding of this relationship.
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