Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.
Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.
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DOI：
10.1016/j.cub.2020.07.039
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发表时间：
2020-10-05
期刊：
影响因子：
--
通讯作者：
Roesch MR
中科院分区：
文献类型：
--
作者：
Schneider KN;Sciarillo XA;Nudelman JL;Cheer JF;Roesch MR
识别他人情绪并相应地调整自己行为的能力对于在任何社会环境中发挥作用都是至关重要的。这种能力在一些精神疾病中受损，比如自闭症和精神病。最近的工作已经确定了前扣带皮层（ACC）和其他参与这一过程的大脑区域。神经记录研究表明，ACC中的神经元在传递给同物和亲身体验时受到奖励或电击的调节。由于先前的研究没有在同一实验中改变奖励和电击，因此尚不清楚观察到的活动是否反映了对同一刺激或与这些刺激相关的效价的结果的关注程度。为了解决这个问题，我们在大鼠执行巴甫洛夫任务时记录下了前扣带皮层，该任务预测了来自另一个房间或同一房间的大鼠是否会收到奖励、电击或什么都没有。与先前的报道一致，我们发现ACC神经元的放电受到记录大鼠及其同种动物的厌恶刺激的调节。其中一些神经元的活动真实地反映了结果的同一性（即，奖励或电击），然而，作为一个整体，神经元群体对奖励和电击以及预测其发生的线索（即，奖励>中性和电击>中性；注意）的反应相似。这些结果表明，在某些社会环境中，前扣带皮层可以处理有关结果（即身份、接受者）的信息，以促进注意力。ACC被认为通过传达他人的情绪来促进同理心和亲社会行为，但它也可能通过与注意力相关的机制来促进社会行为。Schneider等人的研究表明，在注意力服务中，ACC处理有关自己和他人的奖惩信息。
The ability to recognize emotions in others and adapt one’s behavior accordingly is critical for functioning in any social context. This ability is impaired in several psychiatric disorders, such as autism and psychopathy. Recent work has identified the anterior cingulate cortex (ACC) among other brain regions involved in this process. Neural recording studies have shown that neurons in ACC are modulated by reward or shock when delivered to a conspecific and when experienced first-hand. Since previous studies do not vary reward and shock within the same experiment, it has been unclear whether the observed activity reflects how much attention is being paid to outcomes delivered to a conspecific or the valence associated with those stimuli. To address this issue, we recorded from ACC as rats performed a Pavlovian task that predicted whether reward, shock, or nothing would be delivered to the rat being recorded from or a conspecific located in the opposite chamber. Consistent with previous reports, we found that the firing of ACC neurons was modulated by aversive stimuli delivered to the recording rat and their conspecific. Activity of some of these neurons genuinely reflected outcome identity (i.e., reward or shock), however the population of neurons as a whole responded similarly for both reward and shock, as well as for cues that predicted their occurrence (i.e., reward >neutral and shock > neutral; attention). These results suggest that ACC can process information about outcomes (i.e., identity, recipient) in the service of promoting attention in some social contexts. ACC is thought to contribute to empathy and prosocial behavior by signaling the emotions of others, but it might also contribute to social behavior via mechanisms related to attention. Schneider et al. show that ACC processes information about rewards and punishments for oneself and others in the service of attention.
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DOI：
10.1126/science.1168488
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hayden BY;Pearson JM;Platt ML
通讯作者：
Platt ML
影响因子：
3.7
作者：
Atsak P;Orre M;Bakker P;Cerliani L;Roozendaal B;Gazzola V;Moita M;Keysers C
通讯作者：
Keysers C
DOI：
10.1523/jneurosci.4715-11.2011
发表时间：
2011-12-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bryden DW;Johnson EE;Tobia SC;Kashtelyan V;Roesch MR
通讯作者：
Roesch MR
影响因子：
3.7
作者：
Bryden, Daniel W.;Brockett, Adam T.;Roesch, Matthew R.
通讯作者：
Roesch, Matthew R.
影响因子：
3.5
作者：
Bryden DW;Burton AC;Kashtelyan V;Barnett BR;Roesch MR
通讯作者：
Roesch MR