Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study.
Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study.
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DOI：
10.1186/1471-2350-13-103
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发表时间：
2012-11-08
影响因子：
--
通讯作者：
Morange PE
中科院分区：
文献类型：
--
作者：
Kallel C;Cohen W;Saut N;Blankenberg S;Schnabel R;Rupprecht HJ;Bickel C;Munzel T;Tregouet DA;Morange PE
血液凝固是冠状动脉疾病（CAD）的重要决定因素。可溶性内皮蛋白C受体（sEPCR）可能是高凝状态的生物标志物。我们前瞻性地研究了血浆sEPCR水平与心血管事件（CVE）风险之间的关系。我们测量了来自AtheroGene队列的1673例冠心病患者（521例急性冠脉综合征[ACS]， 1152例稳定型心绞痛[SAP]）的基线sEPCR水平。在平均3.7年的随访期间，136人有CVE。此外，这些CAD患者中有891人被PROCR rs867186 （Ser219Gly）变异基因分型。基线时，ACS和SAP患者的sEPCR水平相似（中位数分别为111和115 ng/mL； p=0.20）。sEPCR水平升高与多种心血管危险因素相关，包括性别（p=0.006）、可溶性组织因子水平（p=0.0001）、糖尿病（p=0.0005）以及反映肾功能受损的因素，如肌酐和胱抑制素C （p<0.0001）。sEPCR水平与CVE风险无显著相关性（有和无CVE个体的中位数分别为110和114 ng/mL； p=0.68）。发现rs867186变异解释了59%的sEPCR水平变异（p<10-200），但与CVE风险无关。我们的研究结果表明，在CAD患者中，循环sEPCR水平与经典心血管危险因素和肾脏损害有关，但与CVE的长期发病率无关。
Blood coagulation is an essential determinant of coronary artery disease (CAD). Soluble Endothelial Protein C Receptor (sEPCR) may be a biomarker of a hypercoagulable state. We prospectively investigated the relationship between plasma sEPCR levels and the risk of cardiovascular events (CVE). We measured baseline sEPCR levels in 1673 individuals with CAD (521 with acute coronary syndrome [ACS] and 1152 with stable angina pectoris [SAP]) from the AtheroGene cohort. During a median follow up of 3.7 years, 136 individuals had a CVE. In addition, 891 of these CAD patients were genotyped for the PROCR rs867186 (Ser219Gly) variant. At baseline, sEPCR levels were similar in individuals with ACS and SAP (median: 111 vs. 115 ng/mL respectively; p=0.20). Increased sEPCR levels were found to be associated with several cardiovascular risk factors including gender (p=0.006), soluble Tissue Factor levels (p=0.0001), diabetes (p=0.0005), and factors reflecting impaired renal function such as creatinine and cystatin C (p<0.0001). sEPCR levels were not significantly associated with the risk of CVE (median: 110 and 114 ng/mL in individuals with and without future CVE respectively; p=0.68). The rs867186 variant was found to explain 59% of sEPCR levels variability (p<10-200) but did not associate with CVE risk. Our findings show that in patients with CAD, circulating sEPCR levels are related to classical cardiovascular risk factors and renal impairment but are not related to long-term incidence of CVE.
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DOI：
10.1053/j.ajkd.2008.10.044
发表时间：
2009-04
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Bash LD;Erlinger TP;Coresh J;Marsh-Manzi J;Folsom AR;Astor BC
通讯作者：
Astor BC
影响因子：
5.3
作者：
Ireland, H;Konstantoulas, CJ;Kurosawa, S
通讯作者：
Kurosawa, S
影响因子：
4.8
作者：
Liaw, PCY;Neuenschwander, PF;Esmon, CT
通讯作者：
Esmon, CT
DOI：
10.1161/atvbaha.109.191551
发表时间：
2009-11-01
影响因子：
8.7
作者：
Ireland, Helen A.;Cooper, Jackie A.;Humphries, Stephen E.
通讯作者：
Humphries, Stephen E.
影响因子：
20.3
作者：
Saposnik, Beatrice;Lesteven, Elodie;Gandrille, Sophie
通讯作者：
Gandrille, Sophie