Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
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DOI：
10.1007/s10519-013-9604-z
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发表时间：
2013-09
影响因子：
2.6
通讯作者：
Porjesz B
中科院分区：
文献类型：
--
作者：
Chorlian DB;Rangaswamy M;Manz N;Wang JC;Dick D;Almasy L;Bauer L;Bucholz K;Foroud T;Hesselbrock V;Kang SJ;Kramer J;Kuperman S;Nurnberger J Jr;Rice J;Schuckit M;Tischfield J;Edenberg HJ;Goate A;Bierut L;Porjesz B
离散时间生存分析(DTSA)被用来评估事件相关振荡(EROS)和CHRM2基因变异与经常饮酒和酒精依赖开始之间的特定年龄相关性。研究对象为2938名12至25岁的青少年和青壮年。结果表明，CHRM2基因变异和ERO危险因素具有随年龄变化较大的危险性。大多数重要的特定年龄关联发生在那些发病年龄在16岁以下的人。这些关联集中在那些有时服用非法药物的受试者。这些结果与那些在很小的时候就开始饮酒的人有更高的酒精依赖率的研究是一致的。遗传和神经生理因素的年龄特异性与最近对青春期大脑发育的研究一致，这些研究发现，在青少年早期到中期，对物质使用障碍的易感性增加。
Discrete time survival analysis (DTSA) was used to assess the age-specific association of event related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2938 adolescents and young adults ages 12 to 25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associations were concentrated in those subjects who at some time took an illicit drug. These results are consistent with studies which associate greater rates of alcohol dependence among those who begin drinking at an early age. The age specificity of the genetic and neurophysiological factors is consistent with recent studies of adolescent brain development, which locate an interval of heightened vulnerability to substance use disorders in the early to mid teens.
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影响因子：
2.1
作者：
Choi, Yoonha;Wijsman, Ellen M.;Weir, Bruce S.
通讯作者：
Weir, Bruce S.
影响因子：
2.9
作者：
Galvan A
通讯作者：
Galvan A
影响因子：
2.9
作者：
Edenberg HJ;Bierut LJ;Boyce P;Cao M;Cawley S;Chiles R;Doheny KF;Hansen M;Hinrichs T;Jones K;Kelleher M;Kennedy GC;Liu G;Marcus G;McBride C;Murray SS;Oliphant A;Pettengill J;Porjesz B;Pugh EW;Rice JP;Rubano T;Shannon S;Steeke R;Tischfield JA;Tsai YY;Zhang C;Begleiter H
通讯作者：
Begleiter H
青少年暴饮暴食改变了小鼠的成人脑神经递质的表达，行为，大脑区域体积和神经化学。
DOI：
10.1111/j.1530-0277.2010.01385.x
发表时间：
2011-04
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Coleman LG Jr;He J;Lee J;Styner M;Crews FT
通讯作者：
Crews FT
影响因子：
6
作者：
Dick, Danielle M.;Agrawal, Arpana;Bierut, Laura J.
通讯作者：
Bierut, Laura J.