Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.
Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population.
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ZFHX3 基因中的 SNP rs2106261 与中国汉族 GeneID 人群中心房颤动的显着相关性
DOI：
10.1007/s00439-010-0912-6
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发表时间：
2011-03
期刊：
影响因子：
5.3
通讯作者：
Wang QK
中科院分区：
文献类型：
--
作者：
Li C;Wang F;Yang Y;Fu F;Xu C;Shi L;Li S;Xia Y;Wu G;Cheng X;Liu H;Wang C;Wang P;Hao J;Ke Y;Zhao Y;Liu M;Zhang R;Gao L;Yu B;Zeng Q;Liao Y;Yang B;Tu X;Wang QK
心房颤动（AF）是临床上最常见的心律失常，占所有卒中的15%。最近的全基因组关联研究（GWAS）确定了两个单核苷酸多态性（SNP），ZFHX 3（锌指同源框3基因）中的rs 2106261和rs7193343以及KCNN 3（编码钾中/小电导钙激活通道，亚家族N，成员3）中的rs 13376333，这些SNP在欧洲血统的多个人群中显示出与AF的显著关联。在这里，我们研究了由650名AF患者和1，447名非AF对照组成的中国汉族GeneID队列，以测试ZFHX 3/KCNN 3和AF的GWAS结果是否可以扩展到不同的种族人群。ZFHX 3中的rs7193343和KCNN 3中的rs 13376333没有检测到显著关联。然而，在ZFHX 3中的rs 2106261与GeneID群体中的AF之间的两个等位基因频率均被确定为显著相关。（校正年龄、性别、高血压、冠状动脉疾病和糖尿病等协变量后，P=0.001; OR=1.32），以及假设加性或隐性模型的基因型频率（分别为OR=1.29，P=0.001和OR=1.77，P =0.00018）。当仅分析孤立性AF病例时，相关性仍然显著（等位基因相关性OR=1.50，P=0.001;加性模型OR=1.45，P=0.001;隐性模型OR=2.24，P=0.000043）。我们的研究结果表明，ZFHX 3中的rs 2106261赋予中国汉族人群AF的显著风险。该研究将ZFHX 3与AF之间的关联扩展到非欧洲血统人群，并提供了16 q22 AF基因座跨种族易感性的第一个证据。
Atrial fibrillation (AF) is the most common cardiac rhythm disorder at the clinical setting and accounts for up to 15% of all strokes. Recent genome-wide association studies (GWAS) identified two single nucleotide polymorphisms (SNPs), rs2106261 and rs7193343 in ZFHX3 (zinc finger homeobox 3 gene) and rs13376333 in KCNN3 (encoding a potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3) that showed significant association with AF in multiple populations of European ancestry. Here, we studied a Chinese Han, GeneID cohort consisting of 650 AF patients and 1,447 non-AF controls to test whether the GWAS findings on ZFHX3/KCNN3 and AF can be expanded to a different ethnic population. No significant association was detected for rs7193343 in ZFHX3 and rs13376333 in KCNN3. However, significant association was identified between rs2106261 in ZFHX3 and AF in the GeneID population for both allelic frequencies (P=0.001 after adjusting for covariates of age, gender, hypertension, coronary artery disease, and diabetes mellitus; OR=1.32), and genotypic frequencies assuming either an additive or recessive model (OR=1.29, P=0.001 and OR=1.77, P =0.00018, respectively). When only lone AF cases were analyzed, the association remained significant (OR=1.50, P=0.001 for allelic association; OR=1.45, P=0.001 for an additive model; OR=2.24, P=0.000043 for a recessive model). Our results indicate that rs2106261 in ZFHX3 confers a significant risk of AF in a Chinese Han population. The study expands the association between ZFHX3 and AF to a non-European ancestry population and provides the first evidence of a cross-race susceptibility of the 16q22 AF locus.
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DOI：
10.1016/j.bbrc.2010.06.042
发表时间：
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