Common variants in KCNN3 are associated with lone atrial fibrillation.
Common variants in KCNN3 are associated with lone atrial fibrillation.
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DOI：
10.1038/ng.537
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发表时间：
2010-03
期刊：
影响因子：
30.8
通讯作者：
Kaeaeb, Stefan
中科院分区：
文献类型：
--
作者：
Ellinor, Patrick T.;Lunetta, Kathryn L.;Glazer, Nicole L.;Pfeufer, Arne;Alonso, Alvaro;Chung, Mina K.;Sinner, Moritz F.;de Bakker, Paul I. W.;Mueller, Martina;Lubitz, Steven A.;Fox, Ervin;Darbar, Dawood;Smith, Nicholas L.;Smith, Jonathan D.;Schnabel, Renate B.;Soliman, Elsayed Z.;Rice, Kenneth M.;Van Wagoner, David R.;Beckmann, Britt-M;van Noord, Charlotte;Wang, Ke;Ehret, Georg B.;Rotter, Jerome I.;Hazen, Stanley L.;Steinbeck, Gerhard;Smith, Albert V.;Launer, Lenore J.;Harris, Tamara B.;Makino, Seiko;Nelis, Mari;Milan, David J.;Perz, Siegfried;Esko, Tonu;Koettgen, Anna;Moebus, Susanne;Newton-Cheh, Christopher;Li, Man;Moehlenkamp, Stefan;Wang, Thomas J.;Kao, W. H. Linda;Vasan, Ramachandran S.;Noethen, Markus M.;MacRae, Calum A.;Stricker, Bruno H. Ch;Hofman, Albert;Uitterlinden, Andre G.;Levy, Daniel;Boerwinkle, Eric;Metspalu, Andres;Topol, Eric J.;Chakravarti, Aravinda;Gudnason, Vilmundur;Psaty, Bruce M.;Roden, Dan M.;Meitinger, Thomas;Wichmann, H-Erich;Witteman, Jacqueline C. M.;Barnard, John;Arking, Dan E.;Benjamin, Emelia J.;Heckbert, Susan R.;Kaeaeb, Stefan
房颤是最常见的持续性心律失常。部分孤立性房颤患者没有明显的心脏病，房颤的遗传性增加。我们试图确定孤立性房颤的常见遗传变异。病例来自德国房颤网络、心脏和血管健康研究、社区动脉粥样硬化风险研究、克利夫兰诊所和马萨诸塞州综合医院。受试者进行了基因分型，输入了HapMap SNPs，并进行了年龄、性别和高血压调整分析。对1,335例孤立性房颤和12,844名参照者进行了荟萃分析。在染色体1q21上发现了一个新的基因座，其中最显著的SNP，rs13376333，调整后的优势比为1.56(P=6.3×10−12)。这种关联在单独发生房颤的两个队列中重复，总的优势比为1.5 2(P=1.83×10−2 1)。Rs13376333是参与心房复极化的钾通道KCNN3的内含子。KCNN3是治疗房颤的一个新的潜在治疗靶点。
Atrial fibrillation (AF) is the most common sustained arrhythmia. A subset of patients with lone AF have no overt heart disease and an increased heritability of AF. We sought to identify common genetic variants underlying lone AF. Cases were from the German AF Network, Heart and Vascular Health Study, Atherosclerosis Risk in Communities Study, Cleveland Clinic, and Massachusetts General Hospital. Subjects were genotyped, HapMap SNPs imputed, and age- sex- and hypertension-adjusted analyses performed. A meta-analysis was conducted using 1,335 cases of lone AF and 12,844 referents. A novel locus on chromosome 1q21 was identified, and the most significant SNP, rs13376333, had an adjusted odds ratio of 1.56 (P=6.3×10−12). This association was replicated in two cohorts with lone AF for an overall odds ratio of 1.52 (P=1.83×10−21). Rs13376333 is intronic to KCNN3, a potassium channel involved in atrial repolarization. KCNN3 represents a novel potential therapeutic target in the treatment of AF.
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影响因子：
39.3
作者：
Arnar, DO;Thorvaldsson, S;Stefansson, K
通讯作者：
Stefansson, K
影响因子：
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作者：
de Bakker, Paul I. W.;Ferreira, Manuel A. R.;Voight, Benjamin F.
通讯作者：
Voight, Benjamin F.
影响因子：
64.8
作者：
Gibbs, RA;Belmont, JW;Tanaka, T
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Tanaka, T
影响因子：
5.3
作者：
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通讯作者：
MacRae, CA
16q22 上 ZFHX3 的序列变异与心房颤动和缺血性中风相关。
影响因子：
30.8
作者：
Gudbjartsson, Daniel F.;Holm, Hilma;Gretarsdottir, Solveig;Thorleifsson, Gudmar;Walters, G. Bragi;Thorgeirsson, Gudmundur;Gulcher, Jeffrey;Mathiesen, Ellisiv B.;Njolstad, Inger;Nyrnes, Audhild;Wilsgaard, Tom;Hald, Erin M.;Hveem, Kristian;Stoltenberg, Camilla;Kucera, Gayle;Stubblefield, Tanya;Carter, Shannon;Roden, Dan;Ng, Maggie C. Y.;Baum, Larry;So, Wing Yee;Wong, Ka Sing;Chan, Juliana C. N.;Gieger, Christian;Wichmann, H-Erich;Gschwendtner, Andreas;Dichgans, Martin;Kuhlenbaeumer, Gregor;Berger, Klaus;Ringelstein, E. Bernd;Bevan, Steve;Markus, Hugh S.;Kostulas, Konstantinos;Hillert, Jan;Sveinbjornsdottir, Sigurlaug;Valdimarsson, Einar M.;Lochen, Maja-Lisa;Ma, Ronald C. W.;Darbar, Dawood;Kong, Augustine;Arnar, David O.;Thorsteinsdottir, Unnur;Stefansson, Kari
通讯作者：
Stefansson, Kari