COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response.
COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response.
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DOI：
10.3390/vaccines8040649
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发表时间：
2020-11-03
期刊：
影响因子：
7.8
通讯作者：
Chand S
中科院分区：
文献类型：
--
作者：
Jain S;Batra H;Yadav P;Chand S
由 SARS-CoV-2 引起的 COVID-19 大流行已成为近几十年来最具破坏性的人道主义灾难，全球死亡人数超过 100 万人。对感染和传播给弱势人群的恐惧严重影响了社会的社会经济地位。为了结束不断增加的感染和死亡人数，并从限制性生活转向日常生活，迫切需要一种有效的疫苗。因此，全球做出了巨大努力，在短短几个月内开发出多种候选疫苗。目前，超过 30 种候选疫苗正在临床试验中进行评估，其中几种正在进行临床前研究。在这里，我们根据用于开发主要候选疫苗的特定疫苗平台对主要候选疫苗进行了审查。我们还讨论了这些候选药物在人类和临床前模型中产生的免疫反应，以确定疫苗的安全性、免疫原性和有效性。最后，还简要回顾了康复后的 COVID-19 患者诱导的免疫反应及其可能对疫苗开发的影响。
With a death toll of over one million worldwide, the COVID-19 pandemic caused by SARS-CoV-2 has become the most devastating humanitarian catastrophe in recent decades. The fear of acquiring infection and spreading to vulnerable people has severely impacted society’s socio-economic status. To put an end to this growing number of infections and deaths as well as to switch from restricted to everyday living, an effective vaccine is desperately needed. As a result, enormous efforts have been made globally to develop numerous vaccine candidates in a matter of months. Currently, over 30 vaccine candidates are under assessment in clinical trials, with several undergoing preclinical studies. Here, we reviewed the major vaccine candidates based on the specific vaccine platform utilized to develop them. We also discussed the immune responses generated by these candidates in humans and preclinical models to determine vaccine safety, immunogenicity, and efficacy. Finally, immune responses induced in recovered COVID-19 patients and their possible vaccine development implications were also briefly reviewed.
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影响因子：
56.9
作者：
Hsieh, Ching-Lin;Goldsmith, Jory A.;McLellan, Jason S.
通讯作者：
McLellan, Jason S.
影响因子：
4.6
作者：
Cunningham, Anthony L.
通讯作者：
Cunningham, Anthony L.
DOI：
10.1038/nrmicro2090
发表时间：
2009-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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影响因子：
4.8
作者：
Ewer K;Sebastian S;Spencer AJ;Gilbert S;Hill AVS;Lambe T
通讯作者：
Lambe T
影响因子：
56.3
作者：
Folegatti, Pedro M.;Bittaye, Mustapha;Gilbert, Sarah
通讯作者：
Gilbert, Sarah