Chimpanzee adenoviral vectors as vaccines for outbreak pathogens.
Chimpanzee adenoviral vectors as vaccines for outbreak pathogens.
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DOI：
10.1080/21645515.2017.1383575
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发表时间：
2017-12-02
影响因子：
4.8
通讯作者：
Lambe T
中科院分区：
文献类型：
--
作者：
Ewer K;Sebastian S;Spencer AJ;Gilbert S;Hill AVS;Lambe T
2014- 2015年西非埃博拉疫情突出表明，新出现的病原体可能导致大规模疾病爆发，并引起人们对未来流行病准备工作的高度重视。在这里，我们讨论了开发针对爆发病原体的疫苗的驱动因素、策略和实际考虑。黑猩猩腺病毒（ChAd）载体已被开发为多种传染病和前列腺癌的候选疫苗。ChAd载体是安全的，并在所有年龄组中诱导抗原特异性细胞和体液免疫，以及避免了人类Ad载体遇到的预先存在的免疫问题。由于这些原因，此类病毒载体提供了一个有吸引力的平台，用于储存疫苗以应急部署，以应对新出现的病原体的威胁性爆发。针对其他一些暴发病原体的疫苗开发工作已经在进行中，我们还将在这里审查这些方法的进展，特别是针对拉沙热、尼帕病毒和中东呼吸综合征的疫苗。
The 2014–15 Ebola outbreak in West Africa highlighted the potential for large disease outbreaks caused by emerging pathogens and has generated considerable focus on preparedness for future epidemics. Here we discuss drivers, strategies and practical considerations for developing vaccines against outbreak pathogens. Chimpanzee adenoviral (ChAd) vectors have been developed as vaccine candidates for multiple infectious diseases and prostate cancer. ChAd vectors are safe and induce antigen-specific cellular and humoral immunity in all age groups, as well as circumventing the problem of pre-existing immunity encountered with human Ad vectors. For these reasons, such viral vectors provide an attractive platform for stockpiling vaccines for emergency deployment in response to a threatened outbreak of an emerging pathogen. Work is already underway to develop vaccines against a number of other outbreak pathogens and we will also review progress on these approaches here, particularly for Lassa fever, Nipah and MERS.
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影响因子：
5.4
作者：
Cockrell, Adam S.;Peck, Kayla M.;Heise, Mark T.
通讯作者：
Heise, Mark T.
影响因子：
6.4
作者：
Arnemo, Marianne;Watle, Sara Sofie Viksmoen;Gjoen, Tor
通讯作者：
Gjoen, Tor
DOI：
10.1016/j.ymthe.2016.11.003
发表时间：
2017-02-01
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Bliss CM;Drammeh A;Bowyer G;Sanou GS;Jagne YJ;Ouedraogo O;Edwards NJ;Tarama C;Ouedraogo N;Ouedraogo M;Njie-Jobe J;Diarra A;Afolabi MO;Tiono AB;Yaro JB;Adetifa UJ;Hodgson SH;Anagnostou NA;Roberts R;Duncan CJ;Cortese R;Viebig NK;Leroy O;Lawrie AM;Flanagan KL;Kampmann B;Imoukhuede EB;Sirima SB;Bojang K;Hill AV;Nébié I;Ewer KJ
通讯作者：
Ewer KJ
DOI：
10.1056/nejmoa1502924
发表时间：
2016-04-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Agnandji ST;Huttner A;Zinser ME;Njuguna P;Dahlke C;Fernandes JF;Yerly S;Dayer JA;Kraehling V;Kasonta R;Adegnika AA;Altfeld M;Auderset F;Bache EB;Biedenkopf N;Borregaard S;Brosnahan JS;Burrow R;Combescure C;Desmeules J;Eickmann M;Fehling SK;Finckh A;Goncalves AR;Grobusch MP;Hooper J;Jambrecina A;Kabwende AL;Kaya G;Kimani D;Lell B;Lemaître B;Lohse AW;Massinga-Loembe M;Matthey A;Mordmüller B;Nolting A;Ogwang C;Ramharter M;Schmidt-Chanasit J;Schmiedel S;Silvera P;Stahl FR;Staines HM;Strecker T;Stubbe HC;Tsofa B;Zaki S;Fast P;Moorthy V;Kaiser L;Krishna S;Becker S;Kieny MP;Bejon P;Kremsner PG;Addo MM;Siegrist CA
通讯作者：
Siegrist CA
影响因子：
5.9
作者：
Clayton, Bronwyn Anne
通讯作者：
Clayton, Bronwyn Anne