New Aspects in the Molecular Basis of Polymer-Associated Infections due to Staphylococci
New Aspects in the Molecular Basis of Polymer-Associated Infections due to Staphylococci
复制标题
葡萄球菌引起的聚合物相关感染的分子基础的新方面
DOI：
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发表时间：
1999
影响因子：
4.5
通讯作者：
G. Peters
中科院分区：
文献类型：
--
作者：
C. Eiff;C. Heilmann;G. Peters
摘要 凝固酶阴性葡萄球菌，尤其是表皮葡萄球菌，可引起与临时植入异物和永久植入异物相关的大多数感染。近年来，聚合物相关葡萄球菌感染的发病机制得到了更好的理解，部分原因是进一步的相关因素的特征。本文介绍了细菌在生物膜形成的两个阶段中所涉及的细菌因素，即细菌在聚合物表面的快速黏附和随后较长时间的聚集期。感染设备上的生物膜通过保护嵌入的葡萄球菌，降低宿主防御和抗菌素杀灭的效果，在感染生物的致病性中发挥重要作用。
Abstract Coagulase-negative staphylococci, particularly Staphylococcus epidermidis, cause the majority of infections associated with both temporarily inserted and permanently implanted foreign bodies. In recent years, the pathogenesis of polymer-associated staphylococcal infection has become better understood, due in part to the characterization of further associated factors. The bacterial factors involved in the two phases of biofilm formation, i.e. the rapid adherence of bacteria to the polymer surface and the subsequent, more prolonged, accumulation phase, are presented in this review. The biofilm present on infected devices plays an important role in the pathogenicity of the infecting organism by protecting the embedded staphylococci and reducing the efficacy of host defenses and antimicrobial killing.
凝固酶阴性葡萄球菌临床分离株中荚膜多糖/粘附素的出现。
DOI：
10.1093/infdis/168.5.1211
发表时间：
1993
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Muller,E;Takeda,S;Shiro,H;Goldmann,D;Pier,GB
通讯作者：
Pier,GB