Electrochemical screening of biomembrane-active compounds in water.
Electrochemical screening of biomembrane-active compounds in water.
复制标题
水中生物膜活性化合物的电化学筛选。
DOI：
10.1016/j.aca.2014.01.009
复制
发表时间：
2014
影响因子：
6.2
通讯作者：
Mohamadi S
中科院分区：
文献类型：
--
作者：
Mohamadi S
在高通量流动系统中，生物膜活性化合物与磷脂单分子膜在Pt/Hg电极上的相互作用通过记录电容电流峰的快速循环伏安图（RCV）得到证实。从数据中估计了化合物对层的影响的检测限。研究的化合物包括类固醇，多环芳烃，三环抗抑郁药和三环吩噻嗪。结果表明，相互作用的程度和类型取决于-（a）芳环和取代基的存在和数量，（B）侧链的存在和组成，（c）分子形状。相互作用仅与化合物的疏水性间接相关。对于选择的三环抗抑郁药和三环吩噻嗪，在水中的检测限与其治疗正常阈值有关。在腐殖酸作为潜在替代物的存在下和在自来水基质中对传感测定进行了测试。该系统可以应用于筛选假定的有害物质和药物，从而允许在供水中对其进行早期检测。测量是在真实的时间内进行的，这意味着每次测定在<10分钟内快速检测到潜在的有毒化合物。这项技术将大大有助于环境安全和健康。
Interactions of biomembrane-active compounds with phospholipid monolayers on microfabricated Pt/Hg electrodes in anon-linehigh throughput flow system are demonstrated by recording capacitance current peak changes as rapid cyclic voltammograms (RCV). Detection limits of the compounds’ effects on the layer have been estimated from the data. Compounds studied include steroids, polycyclic aromatic hydrocarbons, tricyclic antidepressants and tricyclic phenothiazines. The results show that the extent and type of interaction depends on the—(a) presence and number of aromatic rings and substituents, (b) presence and composition of side chains and, (c) molecular shape. Interaction is only indirectly related to compound hydrophobicity. For a selection of tricyclic antidepressants and tricyclic phenothiazines the detection limit in water is related to their therapeutic normal threshold. The sensing assay has been tested in the presence of humic acid as a potential interferent and in a tap water matrix. The system can be applied to the screening of putative hazardous substances and pharmaceuticals allowing for early detection thereof in the water supply. The measurements are made in real time which means that potentially toxic compounds are detected rapidly within <10 min per assay. This technology will contribute greatly to environment safety and health.
登录
查看更多内容
使用量子化学描述符和偏最小二乘法估计多环芳烃的水溶性
DOI：
10.1002/qsar.200710014
发表时间：
2008
期刊：
Qsar & Combinatorial Science
影响因子：
--
作者：
G. Lu;Z. Dang;Xue;Chengfang Yang;X. Yi
通讯作者：
X. Yi
磷脂涂层汞电极在水系统中多核芳烃和其他有机微污染物测定中的初步应用
影响因子：
6.2
作者：
A. Nelson;N. Auffret;J. Readman
通讯作者：
J. Readman
影响因子：
5
作者：
Nerea Ormategui;Shengwen Zhang;I. Loinaz;R. Brydson;A. Nelson;A. Vakurov
通讯作者：
Nerea Ormategui;Shengwen Zhang;I. Loinaz;R. Brydson;A. Nelson;A. Vakurov
影响因子：
3.9
作者：
Bizzotto, D;Nelson, A
通讯作者：
Nelson, A
DOI：
10.1016/0005-2736(90)90035-m
发表时间：
1990-01-29
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
NELSON, A;AUFFRET, N;BORLAKOGLU, J
通讯作者：
BORLAKOGLU, J