Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy
Relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the medulla oblongata in multiple system atrophy
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多系统萎缩心脏副交感神经功能障碍与延髓前后径的关系
DOI：
10.1007/s10286-020-00675-4
复制
发表时间：
2020
影响因子：
5.8
通讯作者：
Yumiko Harada & Masahisa Katsuno
中科院分区：
文献类型：
--
作者：
Masashi Suzuki;Tomohiko Nakamura;Masaaki Hirayama;Miki Ueda;Eriko Imai;Yumiko Harada & Masahisa Katsuno
目的迷走背运动核和模棱两可核的神经退行性变与多系统萎缩（MSA）患者的心脏副交感神经功能障碍有关。歧义核和迷走背运动核位于延髓（MO），控制着身体的自主神经，特别是副交感神经功能。本研究的目的是通过定量分析磁共振成像（MRI）结果指标，探讨心脏副交感神经功能障碍与MSA中MO前后径的关系。方法回顾性评估40例疑似MSA患者和25例年龄和性别匹配的对照组。常规MRI测量两个部位（MO直径- a和-B）的前后径以及中脑和脑桥的直径。通过计算多项自主神经功能测试的z-分数，得出心脏副交感神经功能评分（CP-score）和心脏交感神经功能评分（CS-score）。还研究了分数与测量的脑干直径之间的关系。结果MSA患者cp -评分和cs -评分均显著低于对照组（cp -评分：0.61±0.75比- 0.38±0.52,p< 0.001； cs -评分：0.91±1.06比- 0.57±1.07,p< 0.001）。在MSA患者中，cp评分与MO直径- a显著相关（r= 0.40,p= 0.010）， cs评分与中脑直径显著相关（r= 0.33,p= 0.038）。结论骨骺前径是MSA副交感神经功能障碍的潜在影像学指标。
PurposeNeurodegeneration of the nucleus ambiguus and the dorsal vagal motor nucleus has been implicated in cardiac parasympathetic dysfunction in multiple system atrophy (MSA). The nucleus ambiguus and the dorsal vagal motor nucleus, which are located in the medulla oblongata (MO), control the autonomic—specifically, the parasympathetic—functions of the body. The aim of our study was to investigate the relationship between cardiac parasympathetic dysfunction and the anteroposterior diameter of the MO in MSA by quantitatively analyzing magnetic resonance imaging (MRI) outcome measures.MethodsWe retrospectively assessed 40 consecutive patients with probable MSA and 25 age- and sex-matched controls. The anteroposterior diameter of the MO at two locations (MO diameter-A and -B) and the diameters of the midbrain and pons were measured by conventional MRI. A cardiac parasympathetic function score (CP-score) and cardiac sympathetic function score (CS-score) were generated by calculating thez-scores of multiple autonomic function tests. The relationship between the scores and the measured diameters of the brainstem was also investigated.ResultsThe CP-score and CS-score were significantly lower in the patients with MSA than in the controls (CP-score: 0.61 ± 0.75 vs. − 0.38 ± 0.52,p< 0.001; CS-score: 0.91 ± 1.06 vs. − 0.57 ± 1.07,p< 0.001). Also, in the patients with MSA, the CP-score was significantly correlated with MO diameter-A (r= 0.40,p= 0.010), and the CS-score was significantly correlated with the diameter of the midbrain (r= 0.33,p= 0.038).ConclusionThe anteroposterior diameter of the MO is a potential imaging marker of parasympathetic dysfunction in MSA.
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多系统萎缩-突触核蛋白和神经元变性-
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
根本隆行;柳田俊彦;村上学;吉田眞理
通讯作者：
吉田眞理
影响因子：
4.1
作者：
Reginold, William;Lang, Anthony E.;Mikulis, David J.
通讯作者：
Mikulis, David J.
影响因子：
9.9
作者：
Massey, Luke A.;Jaeger, Hans R.;Micallef, Caroline
通讯作者：
Micallef, Caroline
影响因子：
1.6
作者：
Lin K;Wei L;Huang Z;Zeng Q
通讯作者：
Zeng Q
影响因子：
14.5
作者：
Coon, Elizabeth A.;Sletten, David M.;Singer, Wolfgang
通讯作者：
Singer, Wolfgang