CD147 expression in human gastric cancer is associated with tumor recurrence and prognosis.
CD147 expression in human gastric cancer is associated with tumor recurrence and prognosis.
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人胃癌中 CD147 的表达与肿瘤复发和预后相关
DOI：
10.1371/journal.pone.0101027
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zheng J
中科院分区：
文献类型：
--
作者：
Chu D;Zhu S;Li J;Ji G;Wang W;Wu G;Zheng J
CD 147与多种人类恶性肿瘤的侵袭性相关。在此，我们通过免疫组织化学方法研究了223例胃癌患者中CD 147蛋白的表达，并分析了其与无病生存期和总生存期的关系。CD 147在胃癌组织中的表达高于正常组织。CD 147表达与胃癌浸润、转移及TNM分期有关，而与年龄、性别、分化程度、肿瘤部位及Lauren分期无关。Kaplan-Meier分析证实，CD 147与胃癌患者的无病生存期和总生存期相关;即，CD 147染色阳性患者的无病生存期和总生存期往往较差。此外，考克斯的比例风险分析表明，CD 147是胃癌患者的无病生存和总生存的独立标志物。这些结果证实了CD 147与胃癌侵袭转移的关系，并证明CD 147可能是胃癌复发和预后的一个指标。
CD147 is correlated with tumor aggressiveness in various human malignancies. Here, we investigated CD147 protein expression in 223 patients with gastric cancer by immunohistochemistry and analyzed its association with disease-free and overall survival. CD147 was increased in gastric cancer compared to normal tissues. Additionally, CD147 expression was associated with gastric cancer invasion, metastasis and TNM stage, whereas it was not related to age, sex, differentiation status, tumor site or Lauren classification. Kaplan-Meier analysis confirmed that CD147 was associated with disease-free and overall survival in patients with gastric cancer; i.e., patients with positive CD147 staining tend to have worse disease-free and overall survival. Moreover, Cox's proportional hazards analysis demonstrated that CD147 was an independent marker of disease-free and overall survival for patients with gastric cancer. These results confirm the association of CD147 with gastric cancer invasion and metastasis and prove that CD147 might be an indicator of tumor recurrence and prognosis in gastric cancer.
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影响因子：
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Curran, S;Murray, GI
通讯作者：
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