Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
Comparative Efficacy of Haizao Yuhu Decoction Composed of Different Varieties of Glycyrrhiza in Goiter Rats.
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DOI：
10.1155/2021/4343239
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Zhong G
中科院分区：
文献类型：
--
作者：
Chen F;Li N;Xiu L;Liu H;Chen S;He C;Fan A;Yu X;Wang X;Ge C;Huo M;He J;Zhong G
在中医学中，甘草和海藻是“十八反”之一，理论上不能混用。然而，自古以来，许多报道都描述了使用含有海藻和海藻的化合物来治疗疾病。海藻玉壶汤主要用于治疗甲状腺肿，含有两种成分。《中国药典》正式记载了甘草的三个品种：乌拉尔甘草、胀根甘草和光根甘草。这三个品种在化学成分和药理作用上有一定的差异。本研究的目的是调查是否HYD含有不同品种的甘草和海藻有不同的治疗效果在大鼠甲状腺肿，并阐明任何差异的潜在机制。本研究采用丙基硫氧嘧啶（PTU）复制甲状腺肿模型，然后用含不同品种甘草的HYDs治疗4周，检测相关指标。结果表明，HYD具有抗甲状腺肿作用，减轻甲状腺组织的病理变化，恢复PTU引起的甲状腺功能相关激素的异常水平。含甘草的HYD对PTU诱导的大鼠甲状腺肿的治疗效果最好。HYD的抗甲状腺肿作用可能通过下丘脑-垂体-甲状腺（HPT）轴发挥作用，抑制Tg和NIS基因的表达，调节甲状腺激素的合成，从而减少TSH对甲状腺细胞的过度刺激。此外，HYD还通过促进甲状腺细胞凋亡和抑制细胞增殖的ERK/RSK 1通路来预防甲状腺肿。结论：三种类型的HYD对甲状腺肿大鼠的治疗效果不同，这可能是由于不同品种的海藻与甘草配伍所致。
In traditional Chinese medicine, Glycyrrhiza and Sargassum are one pair of the “18 incompatible medicaments,” which in theory cannot be used together. However, since ancient times, many reports have described using compounds containing both Glycyrrhiza and Sargassum to treat diseases. Haizao Yuhu Decoction (HYD), which contains both ingredients, is mainly used to treat goiter. Chinese Pharmacopoeia officially recorded three varieties of Glycyrrhiza: Glycyrrhiza uralensis, Glycyrrhiza inflata, and Glycyrrhiza glabra. These three varieties have certain differences in chemical composition and pharmacological effects. The purpose of the present study was to investigate whether the HYD containing different varieties of Glycyrrhiza and Sargassum had different therapeutic effects in rats with goiter and to elucidate the underlying mechanism of any difference. In this study, propylthiouracil (PTU) was used to replicate the goiter model, then HYDs containing different varieties of Glycyrrhiza were used for treatment for four weeks, and then the relevant indicators were tested. The results demonstrated that HYD had antigoiter effects, alleviated the pathological changes in the thyroid tissue, and restored the abnormal serum levels of hormones related to thyroid function induced by PTU. HYD containing Glycyrrhiza uralensis had the best therapeutic effect in rats with PTU-induced goiter. The antigoiter effect of HYD may function through the hypothalamic-pituitary-thyroid (HPT) axis, inhibit the expression of the Tg and NIS genes, and regulate the synthesis of thyroid hormones, thereby reducing the excessive stimulation of TSH in thyroid cells. In addition, HYD also prevented goiter by promoting thyroid cell apoptosis and inhibiting the ERK/RSK1 pathway of cell proliferation. In conclusion, three types of HYD had different therapeutic effects in rats with goiter, which might be caused by the compatibility of different varieties of Glycyrrhiza and Sargassum.
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