Time-Varying Functional Connectivity Decreases as a Function of Acute Nicotine Abstinence.
Time-Varying Functional Connectivity Decreases as a Function of Acute Nicotine Abstinence.
复制标题
DOI：
10.1016/j.bpsc.2020.10.004
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Stein EA
中科院分区：
文献类型：
--
作者：
Fedota JR;Ross TJ;Castillo J;McKenna MR;Matous AL;Salmeron BJ;Menon V;Stein EA
The Nicotine Withdrawal Syndrome (NWS) includes affective and cognitive disruptions whose incidence and severity vary across time during acute abstinence. However, most network-level neuroimaging employs static measures of resting state functional connectivity (rsFC), assume time-invariance, and are thus unable to capture dynamic brain-behavior relationships. Recent advances in rsFC signal processing allow characterization of “time varying functional connectivity” (TVFC), which characterizes network communication between networks that reconfigure over the course of data collection. As such, TVFC may more fully describe network dysfunction related to the NWS. To isolate alterations in the frequency and diversity of communication across network boundaries during acute nicotine abstinence we scanned n=25 cigarette smokers in the nicotine sated and abstinent states and applied a previously-validated method to characterize TVFC at a network and nodal level within the brain. During abstinence, we found brain wide decreases in the frequency of interactions between network nodes in different modular communities (i.e. temporal flexibility; TF). In addition, within a subset of the networks examined the variability of these interactions across community boundaries (i.e. spatiotemporal diversity; STD) also decreased. Finally, within two of these networks the decrease in STD was significantly related to NWS clinical symptoms. Employing multiple measures of TVFC in a within subjects’ design, we characterized a novel set of changes in network communication and link these changes to specific behavioral symptoms of the NWS. These reductions in TVFC provide a meso-scale network description of the relative inflexibility of specific large-scale brain networks during acute abstinence.
登录
查看更多内容
影响因子：
5.7
作者：
Bartra, Oscar;McGuire, Joseph T.;Kable, Joseph W.
通讯作者：
Kable, Joseph W.
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
4.2
作者：
Colamussi, Lauralea;Bovbjerg, Dana H.;Erblich, Joel
通讯作者：
Erblich, Joel
影响因子：
48
作者：
Esteban, Oscar;Markiewicz, Christopher J.;Gorgolewski, Krzysztof J.
通讯作者：
Gorgolewski, Krzysztof J.
影响因子：
4.6
作者：
Batsikadze G;Paulus W;Hasan A;Grundey J;Kuo MF;Nitsche MA
通讯作者：
Nitsche MA