Fluid pumping of peristaltic vessel fitted with elastic valves
Fluid pumping of peristaltic vessel fitted with elastic valves
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装有弹性阀的蠕动容器的流体泵送
DOI：
10.1017/jfm.2021.302
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发表时间：
2021
影响因子：
3.7
通讯作者：
Alexeev, Alexander
中科院分区：
文献类型：
--
作者：
Wolf, Ki Tae;Dixon, J. Brandon;Alexeev, Alexander
采用数值模拟的方法，对装有弹性双叶阀的轴对称蠕动容器内的流体流动进行了研究。在这个模拟淋巴管中产生的流动的仿生系统中，我们研究了阀门和血管特性对带瓣蠕动血管泵送性能的影响。结果表明，阀门通过减少回流，显著提高了泵送效率。然而，阀门的存在增加了粘性阻力，因此与无阀门的容器相比，需要更大的功。当流体以不利的压力梯度泵送且容器收缩波速较低时，阀门的益处最为显著。我们确定了导致最大泵送效率的最佳容器和阀门参数。我们发现，最佳的阀门弹性可以使泵的流量最大化，因为它允许阀门更有效地阻止回流，同时在回流过程中保持低阻力。我们还研究了血管中的泵送，其中血管收缩幅度是不利压力梯度的函数，就像在淋巴管中发现的那样。我们发现，在这种情况下，流量受到收缩血管产生的功的限制，这表明淋巴管中的泵送受到淋巴肌肉性能的限制。鉴于在整个淋巴管系统观察到的瓣膜形态的区域性异质性，这些结果提供了关于这些变化如何在血管的局部生理环境中促进有效的淋巴管运输的洞察。
Using numerical simulations, we probe the fluid flow in an axisymmetric peristaltic vessel fitted with elastic bi-leaflet valves. In this biomimetic system that mimics the flow generated in lymphatic vessels, we investigate the effects of the valve and vessel properties on pumping performance of the valved peristaltic vessel. The results indicate that valves significantly increase pumping by reducing backflow. The presence of valves, however, increases the viscous resistance, therefore requiring greater work compared to valveless vessels. The benefit of the valves is the most significant when the fluid is pumped against an adverse pressure gradient and for low vessel contraction wave speeds. We identify the optimum vessel and valve parameters leading to the maximum pumping efficiency. We show that the optimum valve elasticity maximizes the pumping flow rate by allowing the valve to block the backflow more effectively while maintaining low resistance during the forward flow. We also examine the pumping in vessels where the vessel contraction amplitude is a function of the adverse pressure gradient, as found in lymphatic vessels. We find that, in this case, the flow is limited by the work generated by the contracting vessel, suggesting that the pumping in lymphatic vessels is constrained by the performance of the lymphatic muscle. Given the regional heterogeneity of valve morphology observed throughout the lymphatic vasculature, these results provide insight into how these variations might facilitate efficient lymphatic transport in the vessel's local physiologic context.
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影响因子：
3.5
作者：
Ballard, Matthew;Wolf, Ki T.;Alexeev, Alexander
通讯作者：
Alexeev, Alexander
非牛顿流体在不同波形的扩流管中的蠕动输送
DOI：
10.1016/j.mcm.2007.10.018
发表时间：
2008
期刊：
Math. Comput. Model.
影响因子：
--
作者：
P. Hariharan;V. Seshadri;R. Banerjee
通讯作者：
R. Banerjee
离体羊后肢制剂中的动脉搏动和淋巴形成。
DOI：
10.1113/jphysiol.1988.sp017350
发表时间：
1988
期刊：
The Journal of Physiology
影响因子：
--
作者：
J. Mcgeown;N. McHale;K. Thornbury
通讯作者：
K. Thornbury
影响因子：
2.4
作者：
Rahbar, Elaheh;Moore, James E., Jr.
通讯作者：
Moore, James E., Jr.
L 型 Ca2 通道活性的差异部分是小鼠外周和内脏淋巴管泵送行为的区域二分法的基础。
DOI：
10.1152/ajpheart.00499.2017
发表时间：
2018
期刊：
American journal of physiology. Heart and circulatory physiology
影响因子：
--
作者：
Zawieja,ScottD;Castorena-Gonzalez,JorgeA;Scallan,JoshuaP;Davis,MichaelJ
通讯作者：
Davis,MichaelJ