Disruption of cutaneous feedback alters magnitude but not direction of muscle responses to postural perturbations in the decerebrate cat.
Disruption of cutaneous feedback alters magnitude but not direction of muscle responses to postural perturbations in the decerebrate cat.
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DOI：
10.1007/s00221-010-2281-8
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发表时间：
2010-06
影响因子：
2
通讯作者：
Nichols, T. Richard
中科院分区：
文献类型：
--
作者：
Honeycutt, Claire F.;Nichols, T. Richard
四足动物和两足动物通过广泛调整和方向敏感的肌肉响应来响应支撑表面的水平扰动。自从发现这种方向敏感性以来，人们的兴趣已经转向产生这些反应所必需的关键感觉系统。我们假设皮肤反馈影响肌肉对姿势扰动的反应幅度，但对肌肉反应的方向性影响很小。我们开发了一种改良的前乳头去大脑猫制剂，以评估驱动这种定向敏感肌肉激活以响应支撑表面扰动的感觉机制。这种准备使我们能够灵活地将本体感觉（皮肤和肌肉受体）系统与其他感觉影响隔离开来。我们发现皮肤反馈的丧失会导致背景活动的显着损失，从而导致肌肉对水平扰动的反应较小。然而，肌肉反应的方向特性保持不变。
Quadrupeds and bipeds respond to horizontal perturbations of the support surface with muscular responses that are broadly tuned and directionally sensitive. Since the discovery of this directional sensitivity, interest has turned toward the critical sensory systems necessary to generate these responses. We hypothesize that cutaneous feedback affects the magnitude of muscle responses to postural perturbation but has little effect on the directionality of the muscle response. We developed a modified premammillary decerebrate cat preparation to evaluate the sensory mechanisms driving this directionally sensitive muscle activation in response to support surface perturbation. This preparation allows us the flexibility to isolate the proprioceptive (cutaneous and muscle receptors) system from other sensory influences. We found that loss of cutaneous feedback leads to a significant loss in background activity causing a smaller muscular response to horizontal perturbations. However, the directional properties of the muscular responses remained intact.
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