Biophysical aspects and modelling of ciliary motility.

Biophysical aspects and modelling of ciliary motility.
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生物物理方面和纤毛运动建模。

DOI:
10.1002/cm.970320209
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发表时间:
1995
期刊:
Cell motility and the cytoskeleton.
影响因子:
--
通讯作者:
Satir,P
Satir,P
中科院分区:
--
文献类型:
--
作者:
Holwill,ME;Foster,GF;Hamasaki,T;Satir,P

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粘性力的主导地位,在产生的纤毛推进推力强调。傅立叶分析表明,纤毛弯曲由直线段连接的圆弧组成;这种弧线形状似乎是与弯曲纤毛的分子机制相关的性质,并且不会因细胞器上外部粘性负载的变化而改变。计算机生成的轴丝结构模型的灵活性通过纳入有关微管表面晶格的最新数据来证明。使用该模型的计算机模拟表明,基于随机而不是协调的动力蛋白臂活动的预测与微管在动力蛋白分子场上滑动的实验观察结果定性匹配。
The dominance of viscous forces in the generation of propulsive thrust by cilia is emphasised. Fourier analysis indicates that ciliary bends consist of circular arcs joined by linear segments; this arc‐line shape appears to be a property associated with the molecular mechanism responsible for bending the cilium and is unchanged by variations in the external viscous loading on the organelle. The flexibility of a computer‐generated model of axonemal structure is demonstrated by the incorporation of recent data concerning the surface lattice of the microtubules. Computer simulations using the model show that predictions based on stochastic, rather than co‐ordinated, dynein arm activity provide a qualitative match to experimental observations of microtubules gliding over fields of dynein molecules.
精子鞭毛的非正弦弯曲波。
DOI: --
发表时间: 1965
影响因子: 2.8
作者:
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通讯作者: C. Brokaw
DOI: --
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期刊: Science
影响因子: 56.9
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DOI: --
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影响因子: --
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DOI: --
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DOI: --
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