Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections.
Modulation of Macrophage Immunometabolism: A New Approach to Fight Infections.
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DOI：
10.3389/fimmu.2022.780839
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发表时间：
2022
影响因子：
7.3
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Gauthier T;Chen W
巨噬细胞是在感染期间有助于宿主防御的必需先天免疫细胞。巨噬细胞的一个重要特征是它们对细胞外信号作出反应的能力，以及对这些刺激作出反应而采用不同的表型和功能的能力。在过去十年中积累的证据已经强调了在感染背景下巨噬细胞活化期间代谢重编程的关键作用。因此，理解和操纵感染过程中的巨噬细胞免疫代谢可能对开发治疗策略感兴趣。本文就糖酵解、磷酸戊糖途径、脂肪酸氧化合成、三羧酸循环和氨基酸代谢等5条主要代谢途径及其在寄生虫、细菌和病毒感染以及训练免疫中的维持和调节作用进行综述。最后，我们评估了一些药物，包括临床和开发中使用的药物，是否可以靶向巨噬细胞的免疫代谢，在感染期间的潜在治疗，重点是SARS-CoV 2感染。
Macrophages are essential innate immune cells that contribute to host defense during infection. An important feature of macrophages is their ability to respond to extracellular cues and to adopt different phenotypes and functions in response to these stimuli. The evidence accumulated in the last decade has highlighted the crucial role of metabolic reprogramming during macrophage activation in infectious context. Thus, understanding and manipulation of macrophage immunometabolism during infection could be of interest to develop therapeutic strategies. In this review, we focus on 5 major metabolic pathways including glycolysis, pentose phosphate pathway, fatty acid oxidation and synthesis, tricarboxylic acid cycle and amino acid metabolism and discuss how they sustain and regulate macrophage immune function in response to parasitic, bacterial and viral infections as well as trained immunity. At the end, we assess whether some drugs including those used in clinic and in development can target macrophage immunometabolism for potential therapy during infection with an emphasis on SARS-CoV2 infection.
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