Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.
Calcitonin gene-related peptide (CGRP) receptor antagonists in the treatment of migraine.
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DOI：
10.2165/11534920-000000000-00000
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发表时间：
2010-07
期刊：
影响因子：
6
通讯作者：
Vause CV
中科院分区：
文献类型：
--
作者：
Durham PL;Vause CV
根据临床前和临床研究，神经肽降钙素基因相关肽(CGRP)被认为在偏头痛的潜在病理中发挥核心作用。降钙素基因相关肽及其受体在外周和中枢神经系统广泛表达，参与炎症和伤害性反应的多种细胞类型的调节。硬脑膜内的三叉神经纤维和三叉神经节神经元胞体的外周CGRP释放可能有助于三叉神经痛感受器的外周敏化。同样，三叉神经尾侧核内CGRP的释放可促进伤害性二级神经元和神经胶质细胞的激活。因此，CGRP参与了持续性疼痛、中枢敏感化和痛觉异常的发生和维持，这些都是偏头痛的病理特征。相反，大脑中CGRP的释放很可能具有抗伤害性的功能。本文将重点介绍降钙素基因相关肽受体拮抗剂的研究进展和临床资料，并讨论它们通过调节外周和中枢神经系统内多种细胞类型在偏头痛治疗中的潜在作用。
Based on preclinical and clinical studies, the neuropeptide calcitonin gene-related peptide (CGRP) is proposed to play a central role in the underlying pathology of migraine. CGRP and its receptor are widely expressed in both the peripheral and central nervous system by multiple cell types involved in the regulation of inflammatory and nociceptive responses. Peripheral release of CGRP from trigeminal nerve fibers within the dura and from the cell body of trigeminal ganglion neurons is likely to contribute to peripheral sensitization of trigeminal nociceptors. Similarly, the release of CGRP within the trigeminal nucleus caudalis can facilitate activation of nociceptive second order neurons and glial cells. Thus, CGRP is involved in the development and maintenance of persistent pain, central sensitization, and allodynia, events characteristic of migraine pathology. In contrast, CGRP release within the brain is likely to function in an anti-nociceptive capacity. This review will focus on the development and clinical data on CGRP receptor antagonists as well as discussing their potential roles in migraine therapy via modulation of multiple cell types within the peripheral and central nervous systems.
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影响因子：
5
作者：
Cady, Roger K.;Vause, Carrie V.;Durham, Paul L.
通讯作者：
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影响因子：
2.9
作者：
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作者：
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影响因子：
3.3
作者：
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通讯作者：
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作者：
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通讯作者：
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