Caffeine improves contrast sensitivity of freely moving rats

Caffeine improves contrast sensitivity of freely moving rats
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咖啡因提高自由活动大鼠的对比敏感度

DOI:
10.1016/j.physbeh.2018.11.014
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发表时间:
2019
期刊:
Physiology & Behavior
影响因子:
--
通讯作者:
Shimegi S
Shimegi S
中科院分区:
--
文献类型:
--
作者:
Tsunoda K;Sato A;Kurata R;Mizuyama R;Shimegi S

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咖啡因(1,3,7 -三甲基黄嘌呤)是一种众所周知的中枢神经系统兴奋剂,影响各种大脑功能,如注意力、记忆和感觉。然而,目前尚不清楚咖啡因是否以及如何调节视觉能力,如对比敏感度(CS)和CS-空间频率(SF)关系。为了探讨这些观点,我们在三种SF条件下测试了咖啡因对大鼠知觉CS的影响。采用双选项强迫选择(2AFC)光栅检测任务结合阶梯法测量CS。任务前30 min腹腔注射咖啡因以SF依赖的方式改善CS,其中在大鼠的最佳SF的0.1 周期/度(cpd)时观察到改善效果,而在0.5或1 cpd时则没有。我们得出的结论是,咖啡因,一种日常食用的食物或饮料中的代表性成分,可以提高感知视觉的敏感度。
Caffeine (1, 3, 7-trimethylxanthine) is a well-known central nervous system stimulant that affects various brain functions such as attention, memory and sensation. However, it remains unclear whether and how caffeine modulates visual ability such as contrast sensitivity (CS) and the CS-spatial frequency (SF) relationship. To investigate these points, we tested the effects of caffeine on the perceptual CS of rats under three SF conditions. CS was measured using a two-alternative forced choice (2AFC) grating detection task combined with a staircase method. Intraperitoneal administration of caffeine 30 min prior to the task improved CS in an SF-dependent manner, in which the improving effect was observed at 0.1 cycles/degree (cpd) of the optimal SF for rats but not at 0.5 or 1 cpd. We concluded that caffeine, a representative ingredient contained in foods or drinks consumed daily, leads to an improvement of perceptual visual sensitivity.
通过体内微透析测量大鼠丘脑中乙酰胆碱的状态依赖性释放
DOI: --
发表时间: 1994
影响因子: 5.3
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发表时间: 1971
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