The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.
The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.
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DOI：
10.1016/j.chom.2011.11.010
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发表时间：
2012-01-19
影响因子：
30.3
通讯作者：
Emerman M
中科院分区：
文献类型：
--
作者：
Compton AA;Hirsch VM;Emerman M
APOBEC3G (A3G) 是一种抑制逆转录病毒的宿主胞苷脱氨酶。 HIV 和相关灵长类慢病毒编码 Vif，它通过诱导 A3G 降解来抵消 A3G。这种 Vif 介导的 A3G 抑制具有物种特异性，表明 A3G-Vif 相互作用随着灵长类慢病毒适应宿主而进化。我们研究了四个非洲绿猴 (AGM) 亚种中 A3G-Vif 相互作用的进化动态，每个亚种都天然感染了不同的猿猴免疫缺陷病毒 (SIV)。我们在两个 AGM 亚种的 A3G 中发现了单个氨基酸的变化，使其对 Vif 蛋白具有抗性，但来自自然感染这些亚种的病毒的 Vif 除外。此外，AGM 的实验感染表明 Vif 可以快速适应这些出现的 Vif 抗性 A3G 基因型。这些数据表明，尽管 SIV 感染在其自然宿主中通常不致病，但它会在 AGM 群体中选择 Vif 抗性形式的 A3G，从而推动 Vif 逆进化和功能分歧。
APOBEC3G (A3G) is a host cytidine deaminase that inhibits retroviruses. HIV and related primate lentiviruses encode Vif, which counteracts A3G by inducing its degradation. This Vif-mediated A3G inhibition is species-specific, suggesting that the A3G-Vif interaction has evolved as primate lentiviruses have adapted to their hosts. We examined the evolutionary dynamics of the A3G-Vif interaction within four African Green Monkey (AGM) subspecies, which are each naturally infected with a distinct simian immunodeficiency virus (SIV). We identified single amino acid changes within A3G in two AGM subspecies that render it resistant to Vif proteins, except for Vif from the viruses that naturally infect these subspecies. Moreover, experimental infection of AGMs shows that Vif can rapidly adapt to these arising Vif-resistant A3G genotypes. These data suggest that despite being generally non-pathogenic in its natural host, SIV infection selects for Vif-resistant forms of A3G in AGM populations, driving Vif counter-evolution and functional divergence.
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影响因子：
64.8
作者：
Keele, Brandon F.;Jones, James Holland;Terio, Karen A.;Estes, Jacob D.;Rudicell, Rebecca S.;Wilson, Michael L.;Li, Yingying;Learn, Gerald H.;Beasley, T. Mark;Schumacher-Stankey, Joann;Wroblewski, Emily;Mosser, Anna;Raphael, Jane;Kamenya, Shadrack;Lonsdorf, Elizabeth V.;Travis, Dominic A.;Mlengeya, Titus;Kinsel, Michael J.;Else, James G.;Silvestri, Guido;Goodall, Jane;Sharp, Paul M.;Shaw, George M.;Pusey, Anne E.;Hahn, Beatrice H.
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D'Aquila, Richard T.
影响因子：
5.4
作者：
Koning, Fransje A.;Newman, Edmund N. C.;Malim, Michael H.
通讯作者：
Malim, Michael H.
影响因子：
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作者：
Sheehy, AM;Gaddis, NC;Malim, MH
通讯作者：
Malim, MH
影响因子：
5.4
作者：
Ling, BH;Apetrei, C;Marx, PA
通讯作者：
Marx, PA