Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz.
Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz.
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DOI：
10.1038/nature08200
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发表时间：
2009-07-23
期刊：
影响因子：
64.8
通讯作者：
Hahn, Beatrice H.
中科院分区：
文献类型：
--
作者：
Keele, Brandon F.;Jones, James Holland;Terio, Karen A.;Estes, Jacob D.;Rudicell, Rebecca S.;Wilson, Michael L.;Li, Yingying;Learn, Gerald H.;Beasley, T. Mark;Schumacher-Stankey, Joann;Wroblewski, Emily;Mosser, Anna;Raphael, Jane;Kamenya, Shadrack;Lonsdorf, Elizabeth V.;Travis, Dominic A.;Mlengeya, Titus;Kinsel, Michael J.;Else, James G.;Silvestri, Guido;Goodall, Jane;Sharp, Paul M.;Shaw, George M.;Pusey, Anne E.;Hahn, Beatrice H.
非洲灵长类动物自然感染了40多种不同的猿猴免疫缺陷病毒（SIV），其中两种已经跨越物种障碍，产生了1型和2型人类免疫缺陷病毒（HIV-1和HIV-2）。然而，与人类病毒不同的是，SIV通常不会在其自然宿主中引起获得性免疫缺陷综合征（AIDS）。在这里，我们表明，SIVcpz，HIV-1的直接前体，在自由放养的黑猩猩中是致病的。通过对坦桑尼亚贡贝国家公园的两个习惯性黑猩猩社区的94名成员进行9年多的跟踪调查，我们发现，与未感染的黑猩猩（n = 77）相比，感染SIVcpz的黑猩猩（n = 17）的年龄校正死亡风险高出10至16倍。我们还发现，SIVcpz感染的女性比未感染的女性更不容易分娩，婴儿死亡率更高。免疫组织化学和原位杂交的尸检脾脏和淋巴结样本从三个感染和两个未感染的黑猩猩发现显着的CD 4 + T细胞耗竭在所有感染的个人，高病毒复制和广泛的滤泡树突状细胞病毒陷阱在其中之一的证据。一名女性在感染SIVcpz后3年内死亡，其组织病理学结果与终末期艾滋病一致。这些结果表明，SIVcpz与HIV-1一样，与进行性CD 4 + T细胞丢失、淋巴组织破坏和过早死亡有关。这些发现挑战了所有自然SIV感染都是非致病性的流行观点，并表明SIVcpz对野生黑猩猩的健康，生殖和寿命产生了实质性的负面影响。
African primates are naturally infected with over 40 different simian immunodeficiency viruses (SIVs), two of which have crossed the species barrier and generated human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2). Unlike the human viruses, however, SIVs do not generally cause acquired immunodeficiency syndrome (AIDS) in their natural hosts. Here we show that SIVcpz, the immediate precursor of HIV-1, is pathogenic in free-ranging chimpanzees. By following 94 members of two habituated chimpanzee communities in Gombe National Park, Tanzania, for over 9 years, we found a 10- to 16-fold higher age-corrected death hazard for SIVcpz-infected (n = 17) compared to uninfected (n = 77) chimpanzees. We also found that SIVcpz-infected females were less likely to give birth and had a higher infant mortality rate than uninfected females. Immunohistochemistry and in situ hybridization of post-mortem spleen and lymph node samples from three infected and two uninfected chimpanzees revealed significant CD4+ T-cell depletion in all infected individuals, with evidence of high viral replication and extensive follicular dendritic cell virus trapping in one of them. One female, who died within 3 years of acquiring SIVcpz, had histopathological findings consistent with end-stage AIDS. These results indicate that SIVcpz, like HIV-1, is associated with progressive CD4+ T-cell loss, lymphatic tissue destruction and premature death. These findings challenge the prevailing view that all natural SIV infections are non-pathogenic and suggest that SIVcpz has a substantial negative impact on the health, reproduction and lifespan of chimpanzees in the wild.
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影响因子：
56.9
作者：
Keele, Brandon F.;Van Heuverswyn, Fran;Hahn, Beatrice H.
通讯作者：
Hahn, Beatrice H.
影响因子：
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