Cryoablation of early-stage primary lung cancer.
Cryoablation of early-stage primary lung cancer.
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DOI：
10.1155/2014/521691
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发表时间：
2014
影响因子：
--
通讯作者：
Jinzaki M
中科院分区：
文献类型：
--
作者：
Inoue M;Nakatsuka S;Jinzaki M
在世界范围内，肺癌是最常见的诊断癌症，肺叶切除术是早期非小细胞肺癌（NSCLC）的金标准治疗。然而，由于各种原因，许多患者是较差的手术候选人。最近，图像引导消融被用于肺肿瘤。冷冻消融术已被应用于治疗各种非充气器官中的癌症;最近它已被应用于治疗肺肿瘤。由于冰球可以通过计算机断层扫描（CT）检测到，因此肺肿瘤的冷冻消融是在CT引导下进行的。2005年报道了其首次临床应用，并在一些研究中报告了其可行性。轻微并发症的发生率很高（高达70.5%），但严重并发症很少（高达1%）。最常见的并发症是气胸，大多数病例不需要进一步干预。局部疗效取决于肿瘤大小和肿瘤附近是否存在厚血管。早期NSCLC患者冷冻消融术后3年中期生存率为77%-88%。虽然手术是治疗此类患者的金标准，但冷冻消融术的初步结果是有希望的。本文就冷冻消融治疗原发性肺肿瘤的研究现状作一综述。
Worldwide, lung cancer is the most commonly diagnosed cancer, and lobectomy is the gold-standard treatment for early-stage non-small cell lung cancer (NSCLC). However, many patients are poor surgical candidates for various reasons. Recently, image-guided ablation is being used for lung tumors. Cryoablation has been applied for the treatment of cancer in various nonaerated organs; recently it has been adapted to the treatment of lung tumors. Since an ice ball can be detected by computed tomography (CT), cryoablation of lung tumors is performed under CT guidance. Its first clinical application was reported in 2005, and it has been reported to be feasible in a few studies. Minor complications occurred at a high frequency (up to 70.5%), but major complications were rare (up to 1%). The most common complication is pneumothorax, and most cases need no further intervention. Local efficacy depends on tumor size and presence of a thick vessel close to the tumor. Midterm survival after cryoablation is 77%–88% at 3 years in patients with early-stage NSCLC. Although surgery is the gold-standard treatment for such patients, the initial results of cryoablation are promising. In this paper, the current status of cryoablation for primary lung tumors is reviewed.
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影响因子：
2.5
作者：
Pennathur A;Abbas G;Schuchert MJ;Landreneau RJ;Luketich JD
通讯作者：
Luketich JD
DOI：
10.1016/j.jtcvs.2008.08.034
发表时间：
2009-01-01
影响因子：
6
作者：
Lanuti, Michael;Sharma, Amita;Shepard, Jo-Anne O.
通讯作者：
Shepard, Jo-Anne O.
DOI：
10.1016/j.jtcvs.2004.10.019
发表时间：
2005-03-01
影响因子：
6
作者：
Fernando, HC;De Hoyos, A;Luketich, JD
通讯作者：
Luketich, JD
影响因子：
19.7
作者：
Simon, Caroline J.;Dupuy, Damian E.;Mayo-Smith, William W.
通讯作者：
Mayo-Smith, William W.
影响因子：
2.9
作者：
Hinshaw, J. Louis;Littrup, Peter J.;Brace, Christopher L.
通讯作者：
Brace, Christopher L.