Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study.
Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways: an international validation study.
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DOI：
10.1371/journal.pone.0011712
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发表时间：
2010-07-22
期刊：
影响因子：
3.7
通讯作者：
Beer DG
中科院分区：
文献类型：
--
作者：
Bryant CM;Albertus DL;Kim S;Chen G;Brambilla C;Guedj M;Arima C;Travis WD;Yatabe Y;Takahashi T;Brambilla E;Beer DG
肺腺癌（AD）是肺癌的主要类型，表现出显著的形态学和分子异质性。我们试图通过对432例AD样本进行基因表达分析，并研究27种已知癌症相关途径与AD亚型、临床特征和患者生存率之间的关联，来了解这种异质性。AD的无监督聚类和基因表达富集分析揭示了细胞增殖是将肿瘤分成亚组的最重要途径。此外，细胞增殖增加的AD表现出明显较差的结果和增加的实体AD亚型成分。此外，我们发现，与没有实体成分的肿瘤相比，具有任何实体成分的肿瘤的存活率降低。这些结果导致了使用相对简单的肿瘤病理学检查来确定其侵袭性和患者预后的可能性。其他结果表明，能够使用类似的方法来确定患者对靶向治疗的敏感性。然后，我们使用来自亚洲（N = 87）和欧洲（N = 89）的两个独立AD队列，使用相同的分析程序证明了这些结果的一致性。
Lung adenocarcinoma (AD) represents a predominant type of lung cancer demonstrating significant morphologic and molecular heterogeneity. We sought to understand this heterogeneity by utilizing gene expression analyses of 432 AD samples and examining associations between 27 known cancer-related pathways and the AD subtype, clinical characteristics and patient survival. Unsupervised clustering of AD and gene expression enrichment analysis reveals that cell proliferation is the most important pathway separating tumors into subgroups. Further, AD with increased cell proliferation demonstrate significantly poorer outcome and an increased solid AD subtype component. Additionally, we find that tumors with any solid component have decreased survival as compared to tumors without a solid component. These results lead to the potential to use a relatively simple pathological examination of a tumor in order to determine its aggressiveness and the patient's prognosis. Additional results suggest the ability to use a similar approach to determine a patient's sensitivity to targeted treatment. We then demonstrated the consistency of these findings using two independent AD cohorts from Asia (N = 87) and Europe (N = 89) using the identical analytic procedures.
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影响因子：
9.2
作者：
Pepicelli, CV;Lewis, PM;McMahon, AP
通讯作者：
McMahon, AP
DOI：
10.1093/jnci/djn389
发表时间：
2008-12-03
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Jemal A;Thun MJ;Ries LA;Howe HL;Weir HK;Center MM;Ward E;Wu XC;Eheman C;Anderson R;Ajani UA;Kohler B;Edwards BK
通讯作者：
Edwards BK
影响因子：
82.9
作者：
Beer, DG;Kardia, SLR;Hanash, S
通讯作者：
Hanash, S
影响因子：
11.2
作者：
Ebi, Hiromichi;Tomida, Shuta;Takahashi, Takashi
通讯作者：
Takahashi, Takashi
影响因子：
64.8
作者：
Weir, Barbara A.;Woo, Michele S.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew