Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma.
Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma.
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透明细胞肾细胞癌个体化泛素预后特征的开发
DOI：
10.3389/fcell.2021.684643
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发表时间：
2021
影响因子：
5.5
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Wu Y;Zhang X;Wei X;Feng H;Hu B;Deng Z;Liu B;Luan Y;Ruan Y;Liu X;Liu Z;Liu J;Wang T
肾透明细胞癌（Clear cell renal cell carcinoma，ccRCC）是泌尿生殖系统常见的肿瘤类型，预后差。泛素依赖性修饰系统已被报道在多种恶性肿瘤中，并影响肿瘤的发生和发展。然而，泛素在ccRCC中的分子特征和预后价值尚未系统报道。在我们的研究中，从癌症基因组图谱（TCGA）队列中鉴定了204个差异表达的泛素相关基因（URG），包括141个上调和63个下调的URG。通过对不同URG的考克斯回归分析鉴定了总共7个预后相关URG（CDCA 3、CHFR、C 0 R 0 6、RNF 175、TRIM 72、VAV 3和WDR 72），并用于构建预后特征。Kaplan-Meier分析证实，高危患者预后较差（P = 1.11e-16），受试者工作特征（ROC）曲线下预测面积1年为0.735，3年为0.702，5年为0.744，显示出良好的预测准确性。分层分析显示，基于URG的预后特征可用于评估ccRCC中的肿瘤进展。进一步分析证实，该信号是与ccRCC患者预后相关的独立预后因素，有助于揭示ccRCC的分子机制，为ccRCC提供潜在的诊断和预后标志物。
Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression. However, the molecular characteristics and prognostic value of ubiquitin in ccRCC have not been systematically reported. In our study, 204 differentially expressed ubiquitin related genes (URGs) were identified from The Cancer Genome Atlas (TCGA) cohort, including 141 up-regulated and 63 down-regulated URGs. A total of seven prognostic related URGs (CDCA3, CHFR, CORO6, RNF175, TRIM72, VAV3, and WDR72) were identified by Cox regression analysis of differential URGs and used to construct a prognostic signature. Kaplan-Meier analysis confirmed that high-risk patients had a worse prognosis (P = 1.11e-16), and the predicted area under the receiver operating characteristic (ROC) curves were 0.735 at 1 year, 0.702 at 3 years, and 0.744 at 5 years, showing good prediction accuracy. Stratified analysis showed that the URGs-based prognostic signature could be used to evaluate tumor progression in ccRCC. Further analysis confirmed that the signature is an independent prognostic factor related to the prognosis of ccRCC patients, which may help to reveal the molecular mechanism of ccRCC and provide potential diagnostic and prognostic markers for ccRCC.
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影响因子：
44.1
作者：
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