Osteoprotegerin, vascular calcification and atherosclerosis.
Osteoprotegerin, vascular calcification and atherosclerosis.
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DOI：
10.1016/j.atherosclerosis.2008.09.033
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发表时间：
2009-06
期刊：
影响因子：
5.3
通讯作者：
Golledge, Jonathan
中科院分区：
文献类型：
--
作者：
Van Campenhout, Ann;Golledge, Jonathan
骨病变与动脉粥样硬化的关联刺激了寻找连接骨骼和血管系统的共同介质。骨保护素（OPG）作为骨代谢的关键调节因子，在血管疾病和钙化中的作用引起了广泛关注。体外和动物模型研究表明，OPG抑制血管钙化。然而，奇怪的是，临床研究表明血清OPG水平升高与血管钙化、冠状动脉疾病、中风和未来的心血管事件相关。这导致了对OPG作为血管疾病生物标志物的潜力的广泛辩论。然而，这种骨调节蛋白影响心血管病理生理的确切意义和机制仍不清楚。越来越多的有价值的研究表明，OPG不仅是一种标志物，也是血管病理学调节成骨、炎症和凋亡反应的介质，因此需要更全面的了解。本文结合近年来的实验研究、动物模型和临床研究成果，对OPG在血管疾病和钙化中的作用进行综述。
The association of bone pathologies with atherosclerosis has stimulated the search for common mediators linking the skeletal and the vascular system. Since its initial discovery as a key regulator in bone metabolism, osteoprotegerin (OPG) has become the subject of intense interest for its role in vascular disease and calcification. Studies in vitro and in animal models suggest that OPG inhibits vascular calcification. Paradoxically however, clinical studies suggest that serum OPG levels increase in association with vascular calcification, coronary artery disease, stroke and future cardiovascular events. This has led to extensive debate on the potential of OPG as a biomarker of vascular disease. However the exact significance and mechanisms by which this bone-regulatory protein influences cardiovascular pathophysiology is still unclear. The need for a more complete picture is being addressed in increasing valuable research indicating OPG as not only a marker but also a mediator of vascular pathology modulating osteogenic, inflammatory and apoptotic responses. By integrating the results of recent experimental research, animal models and clinical studies, this review summarises the present understanding of the role of OPG in vascular disease and calcification.
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