Compact adaptive optics line scanning ophthalmoscope.
Compact adaptive optics line scanning ophthalmoscope.
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DOI：
10.1364/oe.17.010242
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发表时间：
2009-06-08
期刊：
影响因子：
3.8
通讯作者：
Hammer DX
中科院分区：
文献类型：
--
作者：
Mujat M;Ferguson RD;Iftimia N;Hammer DX
我们已经开发出一种紧凑的视网膜成像仪，集成自适应光学（AO）到线扫描检眼镜（LSO）。台式AO-LSO仪器显著降低了研究型AO扫描激光检眼镜（AOSLO）的尺寸、复杂性和成本，目的是将自适应光学成像更快地应用于常规临床。AO-LSO仅使用一个移动部件即可生成高分辨率视网膜图像，并显著减少了仪器占用空间和光学元件数量。AO-LSO具有中等视野（5.5度），可更快速有效地获得黄斑或其他目标的蒙太奇。在初步的人类受试者研究中，光感受器可以在中央凹的约0.5 mm内分辨和计数。光感受器计数与先前报道的组织学密切匹配。中心凹无血管区周围的毛细血管以及其中流动的细胞可以被分辨。可以分辨单个神经纤维束，特别是在视神经头附近，以及其他结构，如筛板。除了仪器设计、制造和测试之外，还开发了用于自动图像配准和锥体计数的软件算法。
We have developed a compact retinal imager that integrates adaptive optics (AO) into a line scanning ophthalmoscope (LSO). The bench-top AO-LSO instrument significantly reduces the size, complexity, and cost of research AO scanning laser ophthalmoscopes (AOSLOs), for the purpose of moving adaptive optics imaging more rapidly into routine clinical use. The AO-LSO produces high resolution retinal images with only one moving part and a significantly reduced instrument footprint and number of optical components. The AO-LSO has a moderate field of view (5.5 deg), which allows montages of the macula or other targets to be obtained more quickly and efficiently. In a preliminary human subjects investigation, photoreceptors could be resolved and counted within ~0.5 mm of the fovea. Photoreceptor counts matched closely to previously reported histology. The capillaries surrounding the foveal avascular zone could be resolved, as well as cells flowing within them. Individual nerve fiber bundles could be resolved, especially near the optic nerve head, as well as other structures such as the lamina cribrosa. In addition to instrument design, fabrication, and testing, software algorithms were developed for automated image registration and cone counting.
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