Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis.
Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis.
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DOI：
10.3389/fcimb.2020.595029
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发表时间：
2020
影响因子：
5.7
通讯作者：
Briken V
中科院分区：
文献类型：
--
作者：
Augenstreich J;Briken V
结核分枝杆菌（Mycobacterium tuberculosis，Mtb）是一种非常成功的病原体，严格适应人类和结核病的原因。其成功与其通过使用不同性质的毒力因子库来抑制宿主细胞内在免疫应答的能力有关。它已经进化为合成一系列复杂的脂质，这些脂质形成外膜，也可以被释放进入宿主细胞膜。此外，Mtb的分泌蛋白效应物进入宿主细胞胞质溶胶以与宿主细胞蛋白相互作用。我们简要地讨论了目前的模型，涉及ESX-1型7分泌系统和结核分枝杆菌脂质phthiocerol dimycoserosate（PDIM），结核分枝杆菌如何创建吞噬体膜孔，让结核分枝杆菌蛋白质进入宿主细胞胞质溶胶。我们提供了具有效应子功能的Mtb分泌蛋白的详尽列表。它们修饰（大多数抑制但有时激活）宿主细胞途径，例如：吞噬体成熟、细胞死亡、细胞因子应答、异种吞噬、经由NADPH氧化酶2（NOX 2）的活性氧（ROS）应答、经由NO合酶2（NOS 2）的一氧化氮（NO）应答和经由MHC I类和II类分子的抗原呈递。我们讨论了每个脂质和蛋白质效应子的宿主细胞靶点以及结核分枝杆菌效应子对细菌毒力的重要性。
Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell intrinsic immune responses by using an arsenal of virulence factors of different nature. It has evolved to synthesize a series of complex lipids which form an outer membrane and may also be released to enter host cell membranes. In addition, secreted protein effectors of Mtb are entering the host cell cytosol to interact with host cell proteins. We briefly discuss the current model, involving the ESX-1 type seven secretion system and the Mtb lipid phthiocerol dimycoserosate (PDIM), of how Mtb creates pores in the phagosomal membrane to allow Mtb proteins to access to the host cell cytosol. We provide an exhaustive list of Mtb secreted proteins that have effector functions. They modify (mostly inhibit but sometimes activate) host cell pathways such as: phagosome maturation, cell death, cytokine response, xenophagy, reactive oxygen species (ROS) response via NADPH oxidase 2 (NOX2), nitric oxide (NO) response via NO Synthase 2 (NOS2) and antigen presentation via MHC class I and class II molecules. We discuss the host cell targets for each lipid and protein effector and the importance of the Mtb effector for virulence of the bacterium.
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DOI：
10.4049/jimmunol.1601199
发表时间：
2017-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Athman JJ;Sande OJ;Groft SG;Reba SM;Nagy N;Wearsch PA;Richardson ET;Rojas R;Boom WH;Shukla S;Harding CV
通讯作者：
Harding CV
影响因子：
5.7
作者：
Arbues, Ainhoa;Lugo-Villarino, Gean Carlo;Astarie-Dequeker, Catherine
通讯作者：
Astarie-Dequeker, Catherine
影响因子：
6.7
作者：
Astarie-Dequeker C;Le Guyader L;Malaga W;Seaphanh FK;Chalut C;Lopez A;Guilhot C
通讯作者：
Guilhot C
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.5
作者：
Beatty, WL;Rhoades, ER;Russell, DG
通讯作者：
Russell, DG