Multiple metals influence distinct properties of the Arabidopsis circadian clock.
Multiple metals influence distinct properties of the Arabidopsis circadian clock.
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DOI：
10.1371/journal.pone.0258374
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Davis SJ
中科院分区：
文献类型：
--
作者：
Hargreaves JK;Oakenfull RJ;Davis AM;Pullen F;Knight MI;Pitchford JW;Davis SJ
昼夜节律协调内源性事件和外部信号，对生物功能是必不可少的。当环境污染物影响这些节律时，生物体可能会经历健康后果，如生长减慢或对病原体的易感性增加。在自然环境中，植物可能会暴露在各种工业和农业土壤污染物中。在这里，我们研究了在根-互作环境中添加不同的金属盐如何影响通过启动子：荧光素酶系统测量的节律。人们发现，这些环境变化的后果是多种多样和复杂的。因此，除了传统的傅立叶分析外，我们还应用了新的基于小波的谱假设检验和聚类方法来组织和理解数据。我们能够对这些金属盐的广泛反应进行分类，包括增加或减少周期，或导致缺乏精确度或扰乱任何有意义的周期。我们的方法是通用的，可以应用于发现广泛的生物时间序列数据中的共同响应和隐藏结构。
Circadian rhythms coordinate endogenous events with external signals, and are essential to biological function. When environmental contaminants affect these rhythms, the organism may experience fitness consequences such as reduced growth or increased susceptibility to pathogens. In their natural environment plants may be exposed to a wide range of industrial and agricultural soil pollutants. Here, we investigate how the addition of various metal salts to the root-interaction environment can impact rhythms, measured via the promoter:luciferase system. The consequences of these environmental changes were found to be varied and complex. Therefore, in addition to traditional Fourier-based analyses, we additionally apply novel wavelet-based spectral hypothesis testing and clustering methodologies to organize and understand the data. We are able to classify broad sets of responses to these metal salts, including those that increase, and those that decrease, the period, or which induce a lack of precision or disrupt any meaningful periodicity. Our methods are general, and may be applied to discover common responses and hidden structures within a wide range of biological time series data.
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