Transplantation of organs from marginal donors.
Transplantation of organs from marginal donors.
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边缘捐献者的器官移植。
DOI：
10.1097/00007890-200110270-00001
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发表时间：
2001
期刊：
影响因子：
6.2
通讯作者：
Peter Neuhaus
中科院分区：
文献类型：
--
作者：
S. G. Tullius;Hans;Peter Neuhaus
The number of patients awaiting organ transplantation has progressively increased during the last decade. Although the number of all registrants tripled during that time period only one-third of patients awaiting kidney or liver grafts and one-half of those hoping for heart grafts were transplanted in 1998. Thus, further progression of the discrepancy between suitable donors and potential recipients on waiting lists will have the consequence of an increasing use of organs from marginal donors. Clearly, organs that would have been thought unsuitable for transplantation not so long ago are currently used for transplantation. Although the engraftment of organs with reduced quality is associated with increasing rates of primary nonor delayed graft function a precise and broadly accepted definition of the term “marginal donor” is currently missing. Consequently, clinical trials based on different selection criteria are difficult to compare. Furthermore, organ-specific aspects reflected by divergent criteria for different organ systems seem to apply. Approaching a general accepted definition various risk factors influencing the quality of the graft will be analyzed, although scoring systems evaluating different risk factors will be suggested. Grafts with reduced quality may show an increased sensitivity toward additional damaging events as ischemia/reperfusion injury or acute rejection episodes. Interventions improving the condition of suboptimal grafts will be discussed. Finally, distinct recipient selection criteria may apply when using marginal grafts. Clinical trials matching grafts from old donors with old recipients are currently investigated. Age-adapted immunosuppressive regimens will be analyzed although an agedependent immune response will be discussed.
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人肾同种异体移植物的分子分析：排斥期间移植物内基因表达的差异。
DOI：
--
发表时间：
1997
期刊：
Kidney international. Supplement.
影响因子：
--
作者：
Suthanthiran,M
通讯作者：
Suthanthiran,M
影响因子：
158.5
作者：
Hariharan, S;Johnson, CP;Stablein, D
通讯作者：
Stablein, D
通过使用创伤死亡供体来改善肾移植再移植的结果。
影响因子：
6.2
作者：
Cecka,JM;Terasaki,PI
通讯作者：
Terasaki,PI
>55岁的活体捐赠者：使用还是不使用？
影响因子：
6.2
作者：
Kerr,SR;Gillingham,KJ;Johnson,EM;Matas,AJ
通讯作者：
Matas,AJ
影响因子：
6.2
作者：
ALMOND, PS;MATAS, A;SCHAFFER
通讯作者：
SCHAFFER