Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications.
Regulation of mitochondrial respiratory chain biogenesis by estrogens/estrogen receptors and physiological, pathological and pharmacological implications.
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DOI：
10.1016/j.bbamcr.2009.06.001
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Yager JD
中科院分区：
文献类型：
--
作者：
Chen JQ;Cammarata PR;Baines CP;Yager JD
There has been increasing evidence pointing to the mitochondrial respiratory chain (MRC) as a novel and important target for the actions of 17β-estradiol(E2) and estrogen receptors (ER) in a number of cell types and tissues that have high demands for mitochondrial energy metabolism. This novel E2-mediated mitochondrial pathway involves the cooperation of both nuclear and mitochondrial ERα and ERβ and their co-activators on the coordinate regulation of both nuclear DNA- and mitochondrial DNA-encoded genes for MRC proteins. In this paper, we have: 1) comprehensively reviewed studies that reveal a novel role of estrogens and ERs in the regulation of MRC biogenesis; 2) discussed their physiological, pathological and pharmacological implications in the control of cell proliferation and apoptosis in relation to estrogen-mediated carcinogenesis, anticancer drug resistance in human breast cancer cells, neuro-protection for Alzheimer’s disease and Parkinson’s disease in brain, cardiovascular protection in human heart and their beneficial effects in lens physiology related to cataract in the eye; and 3) pointed out new research directions to address the key questions in this important and newly emerging area. We also suggest a novel conceptual approach that will contribute to innovative regimines for the prevention or treatment of a wide variety of medical complications based on E2/ER-mediated MRC biogenesis pathway.
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影响因子：
5.3
作者：
Alkayed, NJ;Goto, S;Hurn, PD
通讯作者：
Hurn, PD
影响因子：
2.8
作者：
Abril, Jesus;Lopez de Heredia, Miguel;Nunes, Virginia
通讯作者：
Nunes, Virginia
DOI：
10.1124/jpet.112.192138
发表时间：
2012-09-01
影响因子：
3.5
作者：
Johri, Ashu;Beal, M. Flint
通讯作者：
Beal, M. Flint
DOI：
10.1073/pnas.0800019105
发表时间：
2008-05-13
影响因子：
11.1
作者：
Banci, Lucia;Bertini, Ivano;Palumaa, Peep
通讯作者：
Palumaa, Peep
影响因子：
64.8
作者：
Baines, CP;Kaiser, RA;Molkentin, JD
通讯作者：
Molkentin, JD