Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.
Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.
复制标题
DOI：
10.1111/jne.12856
复制
发表时间：
2020-06
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
30多年前首次证实了体树突分泌。然而，尽管它的存在已被广泛接受，体树突分泌的功能仍然没有完全了解。下丘脑大细胞神经分泌细胞是第一个神经元的表型，其中体细胞树突状细胞分泌被证明是最好的特征的体细胞树突状细胞分泌的功能的神经元。这些神经元分泌的神经肽，加压素和催产素，在一个顺行的方式从他们的轴突在垂体后叶进入血液循环，以调节体液平衡和生殖生理。后叶加压素和催产素的逆行体-树突分泌调节分泌它们的神经元的活性，以及相邻神经元群体的活性，以提供群体内和群体间信号，该信号协调用于控制外周生理的内分泌和自主反应。体-树突加压素和催产素也被认为是大脑中的神经元样信号。有一些证据表明，来自大细胞神经分泌细胞的体细胞-树突分泌物调节了神经元的活动，超出了它们的局部环境，在那里没有含有加压素或催产素的轴突，但是，到目前为止，还没有确凿的证据支持或反对整个大脑中的神经元样信号传导，尽管很难想象在整个大脑中发现的加压素的水平可以通过从相对稀疏的轴突终末区域释放来支持。生成数据以解决这一问题仍然是外地的一个优先事项。
Somato-dendritic secretion was first demonstrated over 30 years ago. However, although its existence has become widely accepted, the function of somato-dendritic secretion is still not completely understood. Hypothalamic magnocellular neurosecretory cells were among the first neuronal phenotypes in which somato-dendritic secretion was demonstrated and are among the neurones for which the functions of somato-dendritic secretion are best characterised. These neurones secrete the neuropeptides, vasopressin and oxytocin, in an orthograde manner from their axons in the posterior pituitary gland into the blood circulation to regulate body fluid balance and reproductive physiology. Retrograde somato-dendritic secretion of vasopressin and oxytocin modulates the activity of the neurones from which they are secreted, as well as the activity of neighbouring populations of neurones, to provide intra-and inter-population signals that coordinate the endocrine and autonomic responses for the control of peripheral physiology. Somato-dendritic vasopressin and oxytocin have also been proposed to act as hormone-like signals in the brain. There is some evidence that somato-dendritic secretion from magnocellular neurosecretory cells modulates the activity of neurones beyond their local environment where there are no vasopressin- or oxytocin-containing axons but, to date, there is no conclusive evidence for, or against, hormone-like signalling throughout the brain, although it is difficult to imagine that the levels of vasopressin found throughout the brain could be underpinned by release from relatively sparse axon terminal fields. The generation of data to resolve this issue remains a priority for the field.
登录
查看更多内容
影响因子：
3.2
作者：
Boudaba, C;Di, S;Tasker, JG
通讯作者：
Tasker, JG
DOI：
10.1152/ajpendo.1998.274.3.e453
发表时间：
1998-03-01
影响因子：
5.1
作者：
Bealer, SL;Crowley, WR
通讯作者：
Crowley, WR
影响因子：
3.3
作者：
Brown, CH;Ludwig, M;Leng, G
通讯作者：
Leng, G
影响因子：
1.7
作者：
Brown, CH;Munro, G;Russell, JA
通讯作者：
Russell, JA
影响因子：
8.3
作者：
Biancardi, Vinicia C.;Son, Sook J.;Stern, Javier E.
通讯作者：
Stern, Javier E.