Supramolecular Architecture of the Coronavirus Particle.

Supramolecular Architecture of the Coronavirus Particle.
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DOI:
10.1016/bs.aivir.2016.08.005
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发表时间:
2016
影响因子:
--
通讯作者:
Buchmeier MJ
Buchmeier MJ
中科院分区:
医学2区
文献类型:
--
作者:
Neuman BW;Buchmeier MJ

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冠状病毒颗粒在感染中起着三个基本的重要作用。病毒粒子提供了跨越宿主细胞质膜传递病毒基因组的手段。对于新合成的基因组来说,病毒粒子也是一种逃逸途径。最后,病毒粒子是一个持久的容器,在细胞之间的旅程中保护基因组。本文综述了冠状病毒结构蛋白的X射线结晶学、核磁共振和低温电子显微镜结构数据,并对每种主要结构蛋白在病毒入侵和组装中的作用进行了综述。讨论了在动脉病毒科和冠状病毒科中发现的核蛋白折叠的潜在的更广泛的保守性,以及冠状病毒结构进化的推测模型。
Coronavirus particles serve three fundamentally important functions in infection. The virion provides the means to deliver the viral genome across the plasma membrane of a host cell. The virion is also a means of escape for newly synthesized genomes. Lastly, the virion is a durable vessel that protects the genome on its journey between cells. This review summarizes the available X-ray crystallography, NMR, and cryoelectron microscopy structural data for coronavirus structural proteins, and looks at the role of each of the major structural proteins in virus entry and assembly. The potential wider conservation of the nucleoprotein fold identified in the Arteriviridae and Coronaviridae families and a speculative model for the evolution of corona-like virus architecture are discussed.
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